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Keywords: Medaka
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Journal Articles
Journal: Development
Development (2021) 148 (11): dev199385.
Published: 9 June 2021
... are often fatal. Consequently, congenital disorders of glycosylation (CDG) in human are rare. We modelled a putative hypomorphic mutation described in an alpha-1,3/1,6-mannosyltransferase (ALG2) index patient (ALG2-CDG) to address the developmental consequences in the teleost medaka ( Oryzias latipes ). We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev199133.
Published: 15 April 2021
... in the neuroretina of medaka fish ( Oryzias latipes ), a well-studied system with which to address vertebrate organ growth. We reveal that a central growth regulator, Igf1 receptor (Igf1r), is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche: the ciliary marginal zone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192500.
Published: 23 November 2020
... genetic programs that can interact with each other during embryogenesis. Here, we have taken advantage of the different span of embryonic development between two distantly related teleosts, zebrafish ( Danio rerio ) and medaka ( Oryzias latipes ) (3 and 9 days, respectively), to explore modularity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev172866.
Published: 23 April 2019
... of the brain in this process is not well clarified. In the present work, we investigated the mRNA levels of corticotropin-releasing hormone b ( crhb ) and its receptors ( crhr1 and crhr2 ), and found that they were upregulated at HT during the crucial period of gonadal sex determination in medaka. In order...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev169698.
Published: 9 November 2018
... specification in progenitors that exit the stem cell niche in the ciliary marginal zone (CMZ). The proper cell-type composition arising from those progenitors is a prerequisite for retinal function. Our findings in the teleost medaka ( Oryzias latipes ) uncover that the Notch-Atoh7 axis continuously patterns...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 265–271.
Published: 15 January 2017
... lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3470–3480.
Published: 1 October 2016
... gastrointestinal tract of the teleost medaka ( Oryzias latipes ). X-ray microcomputed tomography shows a correlation of 3D topography with the functional domains. Analysis of ISCs in proliferation assays and via genetically encoded lineage tracing highlights a stem cell niche in the furrow between the long...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1874–1883.
Published: 1 June 2016
... by the findings in zebrafish, where inhibition of Notch signaling induces MG cell proliferation in the absence of injury ( Conner et al., 2014 ). Interestingly, our results indicate that medaka is highly reminiscent of higher vertebrates regarding the role of Notch in inducing proliferation of MG cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3472–3482.
Published: 15 September 2014
... after embryonic development and following their descendants. Recently, transplantation experiments involving permanently labeled cells revealed multipotent neural stem cells (NSCs) of embryonic origin in the medaka retina. To analyze whether NSC potency is affected by developmental progression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3363–3369.
Published: 1 September 2014
... In vertebrates that have been examined to date, the sexual identity of germ cells is determined by the sex of gonadal somatic cells. In the teleost fish medaka, a sex-determination gene on the Y chromosome, DMY / dmrt1bY , is expressed in gonadal somatic cells and regulates the sexual identity of germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2568–2580.
Published: 1 July 2014
... modification maps from both pluripotent cells and mature organs of medaka fish and compared the profiles with those of human ES cells. We found that a subset of hypomethylated domains harbor H3K27me3 (K27HMDs) and their size positively correlates with the accumulation of H3K27me3. Large K27HMDs are conserved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2787–2797.
Published: 1 July 2013
... organ architecture, morphology and proliferation. We found that mutations of the guanine nucleotide exchange factor ArhGEF18 affect apicobasal polarity of the retinal neuroepithelium in medaka fish. We show that ArhGEF18 -mediated activation of the small GTPase RhoA is required to maintain apicobasal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2283–2287.
Published: 1 July 2012
.... Previously, we have shown that the gene encoding the type II anti-Müllerian hormone receptor, amhrII , is responsible for excessive germ cell proliferation and male-to-female sex reversal in the medaka hotei mutant. In this study, functional analyses in cultured cells and of other amhrII mutant alleles...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 917–928.
Published: 1 March 2012
... their common complex expression pattern remain to be elucidated. Here we performed a pilot screen on 560 genes of the vertebrate model system medaka ( Oryzias latipes ) to systematically identify synexpression groups and investigate their regulatory properties by searching for common regulatory cues. We find...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 151–164.
Published: 1 January 2012
... factors (TFs). Paradoxically, some of these factors are widely expressed in the forebrain, which raises the question of how they can mediate regional differences. To address this issue, we focused on the homeobox TF Six3.2 . With genomic and functional approaches we demonstrate that, in medaka fish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 141–150.
Published: 1 January 2012
... in the medaka model. We generated transgenic medaka lines that express GFP under control of the cathepsin K promoter in osteoclasts starting at 12 days post-fertilization (dpf), or Rankl together with CFP under control of a bi-directional heat-shock promoter. Using long-term confocal time-lapse imaging...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1121–1129.
Published: 15 March 2011
... movement of node cilia, is essential for left-right patterning in the mouse and other vertebrates. However, the identity of the pathways by which nodal flow is interpreted remains controversial as the molecular sensors of this process are unknown. In the current study, we show that the medaka left-right...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2307–2317.
Published: 15 July 2010
... approaches in medaka fish ( Oryzias latipes ) to characterise highly conserved regulatory enhancers responsible for Six6 expression. One of the enhancers drove gene expression in the differentiating and adult retina. A search for transcription factor binding sites, together with luciferase, ChIP assays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1807–1813.
Published: 1 June 2010
...Keiji Inohaya; Yoshiro Takano; Akira Kudo The floor plate is a key organizer that controls the specification of neurons in the central nervous system. Here, we show a new role of the floor plate: segmental pattern formation of the vertebral column. Analysis of a spontaneous medaka mutant, fused...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 507–518.
Published: 1 February 2010
... Zebrafish Lamprey Medaka The vertebrate central nervous system (CNS) forms along the embryonic anteroposterior (AP) axis from the neural plate, a sheet of ectodermal cells that invaginates and transforms into a cylindrical neural tube. Along the dorsoventral (DV) axis, the closed neural tube...
Includes: Supplementary data