...Julien C. Habif; Chao Xie; Carlos de Celis; Kirill Ukhanov; Warren W. Green; Jordan C. Moretta; Lian Zhang; Robert J. Campbell; Jeffrey R. Martens ABSTRACT Olfactory sensory neurons (OSNs) form embryonically and mature perinatally, innervating glomeruli and extending dendrites with multiple cilia...

..., the importance of N-WASP-Arp2/3 signaling in the assembly of neurite architecture in vivo has not been clarified. Here, we demonstrate that N-WASP-Arp2/3 signaling plays a crucial role in the maturation of cerebellar Purkinje cell (PC) dendrites in vivo in mice. N-WASP was expressed and activated in developing...

..., the olfactory system continues to mature and change throughout life as a target of constitutive adult neurogenesis. Our Review synthesises current knowledge of prenatal, postnatal and adult olfactory bulb development, focusing on the maturation, morphology, functions and interactions of its diverse constituent...

.... The trigger for maturation is the secretion of brain-derived neuropeptides, yet the mechanisms controlling the timely onset of this event remain ill-defined. Here, we show that a regulatory feedback circuit controlling the Drosophila neuropeptide Prothoracicotropic hormone (PTTH) triggers maturation onset. We...

...Lei Chen; Natalie H. Toke; Shirley Luo; Roshan P. Vasoya; Rohit Aita; Aditya Parthasarathy; Yu-Hwai Tsai; Jason R. Spence; Michael P. Verzi ABSTRACT As embryos mature, cells undergo remarkable transitions that are accompanied by shifts in transcription factor regulatory networks. Mechanisms driving...

... correlates with a deficit in dermomyotome and myotome marker gene expression, suggesting that Ripply1 promotes myogenesis by terminating Tbx6-dependent inhibition of myogenic maturation. Together, our data suggest that Mesp-b is an intrinsic upstream regulator of skeletal muscle progenitors...

...) represent a novel source of hepatocytes for drug metabolism studies and cell-based therapy for the treatment of liver diseases. These applications are, however, dependent on the ability to generate mature metabolically functional cells from the hPSCs. Reproducible and efficient generation of such cells has...

...Stephen A. Stricker; Toni L. Smythe Before a proper Ca 2+ response is produced at fertilization,oocytes typically undergo a maturation process during which their endoplasmic reticulum (ER) is restructured. In marine protostome worms belonging to the phylum Nemertea, the ER of maturing oocytes forms...

... Amsterdam, The Netherlands 06 10 1995 © 1996 by Company of Biologists 1996 hepatocellular transplantation differentiation maturation morphogenesis carbamoylphosphate synthetase I glutamine synthetase glutamate dehydrogenase α-fetoprotein albumin Hepatocytes...

...F. Z. Sun; R. M. Moor ABSTRACT The present studies have been undertaken to investigate the interactions that occur between the nucleus and cytoplasm of ovine oocytes at various stages during meiotic maturation. We report that the nucleus of ovine fully grown dictyate stage oocytes can...

...Robert L. Varnold; L. Dennis Smith ABSTRACT Though progesterone-induced maturation has been studied extensively in Xenopus oocytes, the mechanism whereby the prophase block arrest is released is not well understood. The current hypothesis suggests that a reduction in cAMP and subsequent...

...Tina D. Patrick; Clare E. Lewer; Virginia M. Pain During the maturation of the oocytes of the frog Xenopus laevis , the rate of protein synthesis shows a twofold increase. Studies of the mechanisms involved in this stimulation have been seriously limited by the lack of an active cell-free...