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Keywords: Mathematical modeling
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Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev193508.
Published: 7 May 2021
... in fish length and yolk utilization is logistic, that is the yolk decays rapidly for a period of time before leveling out. An interesting finding from this study is that yolk utilization reaches its maximum at 84 h post-fertilization. We validated our mathematical models against experimental observations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev195669.
Published: 6 January 2021
...., 2007 ; Ramón y Cajal, 1888 ; Ramón y Cajal, 1899 ) who in fact shared, for the first time, the Nobel prize in Medicine and Physiology. Three-dimensional cell packing Cell shape Scutoid Apico-basal cell intercalation Mathematical modeling Biophysical modeling Summary: This Review...
Journal Articles
Journal: Development
Development (2018) 145 (11): dev161257.
Published: 11 June 2018
...’ model of zebrafish somite formation demonstrates that dynamic gradient scaling in the presomitic mesoderm plays a central role in progression and size control of somitogenesis. Scaling Somite PSM Segmentation clock Fgf gradient Quantitative imaging Mathematical modeling Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
... coordination of cell signaling states. Mathematical modeling Notch signaling Lateral induction Lateral inhibition Author contributions Conceptualization: J.C.L.-E., P.F.-J., M.I.; Methodology: J.C.L.-E., P.F.-J., M.I.; Software: J.C.L.-E., P.F.-J.; Validation: J.C.L.-E.; Formal analysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
..., a transcription factor that patterns the Drosophila dorsal-ventral axis, accumulates at the embryo ventral midline. Here, model-guided experiments show that the inhibitor Cactus shuttles Dorsal to the ventral side. Morphogen Tissue patterning Mathematical modeling Dorsal Cactus Shuttling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2014–2025.
Published: 1 June 2015
... Mathematical modeling Molecular profiling Neural crest Numerical simulation Single cell Chicken In examples that range from primitive streak formation to mechanosensory organogenesis, several embryonic cell populations undergo persistent, directed migration in coordinated groups ( Tarbashevich...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2313–2324.
Published: 1 June 2014
...:3%3C509::AID-CNE8%3E3.0.CO;2-Q Collier J. R. , Monk N. A. M. , Maini P. K. , Lewis J. H. ( 1996 ). Pattern formation by lateral inhibition with feedback: a mathematical model of delta-notch intercellular signalling . J. Theor. Biol. 183 , 429 - 446 . 10.1006/jtbi...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4830–4843.
Published: 15 December 2013
... expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2935–2944.
Published: 15 August 2012
... to this work Competing interests statement The authors declare no competing financial interests. 25 5 2012 © 2012. Neural crest Cranial cell migration Chick Laser capture microdissection qPCR Mathematical modeling Numerical simulation Prevailing models...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2321–2329.
Published: 1 July 2012
... of this tissue, a region lacking Notch1, lFng , and differentiation-related gene expression. We investigated the role of this Dll1 expression through mathematical modeling. Our analysis predicts that the absence of Dll1 ahead of the neurogenic wavefront results in reduced robustness of the lateral inhibition...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2265–2278.
Published: 15 July 2010
... in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (11): 2577–2589.
Published: 1 June 2002
... © 2002. 2002 Drosophila EGFR Mathematical modeling Autocrine loops Mechanisms of intercellular signaling are crucial in development ( Freeman, 2000 ; Wolpert et al., 1998 ). By regulating cell differentiation, migration, growth, and death, cell communication guides...