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Keywords: Mathematical modeling
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Journal Articles
Journal: Development
Development (2024) 151 (9): dev202353.
Published: 9 May 2024
... apoptosis rate and pole signaling. Shape regulation Mechanochemical feedback Morphogens Mathematical modeling Parameter optimization Planarian National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM137953 Multicellular organisms regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (1): dev195669.
Published: 6 January 2021
... Scutoid Apico-basal cell intercalation Mathematical modeling Biophysical modeling The invention of the microscope led to the discovery of the fundamental unit of life: the cell. Yet, the collective organization of cells in tissues is far from obvious under the microscope and requires...
Journal Articles
Journal: Development
Development (2018) 145 (11): dev161257.
Published: 11 June 2018
... in the presomitic mesoderm plays a central role in progression and size control of somitogenesis. Scaling Somite PSM Segmentation clock Fgf gradient Quantitative imaging Mathematical modeling Zebrafish Scaling – matching organ size to body size – is a fundamental property of developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
... coordination of cell signaling states. Mathematical modeling Notch signaling Lateral induction Lateral inhibition Ministerio de Economía, Industria y Competitividad (MINECO, Spain) 10.13039/501100003329 FIS2015-66503-C3-3-P FIS2012-37655-C02-02 Fondo Europeo de Desarrollo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
..., a transcription factor that patterns the Drosophila dorsal-ventral axis, accumulates at the embryo ventral midline. Here, model-guided experiments show that the inhibitor Cactus shuttles Dorsal to the ventral side. Morphogen Tissue patterning Mathematical modeling Dorsal Cactus Shuttling...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (24): 4830–4843.
Published: 15 December 2013
... expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2935–2944.
Published: 15 August 2012
... and trailing cells rather than a homogeneous population. ( A ) Mathematical model schematic. ( B ) Model simulation of NC cell migration. ( C ) Model simulation of NC cell migration [two subpopulations; leaders (yellow) that respond to microenvironmental signals and trailers (red)]. Trailers that respond...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2321–2329.
Published: 1 July 2012
... of this tissue, a region lacking Notch1, lFng , and differentiation-related gene expression. We investigated the role of this Dll1 expression through mathematical modeling. Our analysis predicts that the absence of Dll1 ahead of the neurogenic wavefront results in reduced robustness of the lateral inhibition...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2265–2278.
Published: 15 July 2010
... in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used...
Includes: Supplementary data
Journal Articles