... University, Nashville, TN 37232, USA 17 2 2009 © 2009. 2009 Mouse Olfactory epithelium TGFβ Follistatin p21Cip1 Fgf8 Neuronal progenitor Neurogenesis Mash1 Ngn1 Sox2 Olfactory receptor neuron Cerebral cortex Gene dosage Forkhead or Fox proteins comprise a large...

..., IN 46285, USA 23 9 2005 ©2005. 2005 FGF Vomeronasal organ Neurogenesis Olfactory epithelium Nasal cavity Stem cell Apoptosis Cre recombinase Fgf8 Foxg1 Sox2 Pax6 Mash1 Neurogenin 1 Ncam1 Pyst1 Shh Dlx5 Neuronal progenitor Mouse mutant...

..., dI4 and dI5 neurons, whereas Gsh1 is only expressed in dI4 and dI5 progenitors. Mice lacking Gsh2 exhibit a selective loss of dI3 interneurons that is accompanied by an expansion of the dI2 progenitor domain. In Gsh2 mutant embryos, expression of the proneural bHLH protein Mash1 is downregulated...

... days E9.5 and E18.5. Embryos with complete lack of Wt1 and embryos with selective ablation of the alternatively spliced Wt1( + KTS) isoform both had thinner olfactory epithelia and fewer neuronal progenitor cells than do normal animals. Mash1 and neurogenin 1, two basic helix-loop-helix transcription...

...,at least in part, the Tlx mutant phenotype, because Neurogenins have previously been shown to negatively regulate subpallial (e.g. Mash1 and Dlx genes) gene expression( Fode et al., 2000 ). Interestingly, co-regulation of a common gene by TLX and PAX6 has been shown to occur in eye development...

...Kyuson Yun; Seth Fischman; Jane Johnson; Martin Hrabe de Angelis; Gerry Weinmaster; John L. R. Rubenstein Notch signaling has a central role in cell fate specification and differentiation. We provide evidence that the Mash1 (bHLH) and Dlx1 and Dlx2 (homeobox) transcription factors have...

...Liching Lo; Emma Dormand; Amy Greenwood; David J. Anderson In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 ( Ngn1 and Ngn2 ), and Mash1 are required for sensory and autonomic neurogenesis, respectively. In cultures of neural tube-derived, primitive PNS...

... boundary restrict cells in the dorsal and ventral telencephalon. *Author for correspondence (e-mail: [email protected] ) 28 9 2001 © 2001. 2001 Cortico-striatal boundary Pax6 Mash1 Dlx SFRP2 Mouse Regionalisation of the brain occurs during development...

...Jun Hatakeyama; Koichi Tomita; Tomoyuki Inoue; Ryoichiro Kageyama ABSTRACT Previous analysis of mutant mice has revealed that the bHLH genes Mash1 and Math3 , and the homeobox gene Chx10 are essential for generation of bipolar cells, the interneurons present in the inner nuclear layer of the retina...

... and Gsh2 in cortical and striatal development were studied in single and double loss-of-function mouse mutants. Gsh2 gene function was found to be essential to maintain the molecular identity of early striatal progenitors and in its absence the ventral telencephalic regulatory genes Mash1 and Dlx are lost...

... homologs of achaete-scute complex ( Mash1 ) ( Ascl1 – Mouse Genome Informatics); hairy and enhancer of split1 ( Hes1 ); and the expression of Notch/Notch-ligand system in the fetal and adult mouse lungs, and in the lungs of Mash1 - or Hes1 -deficient mice. Immunohistochemical studies revealed that Mash1...

...Toru Kondo; Martin Raff ABSTRACT An intracellular timer in oligodendrocyte precursor cells is thought to help control the timing of their differentiation. We show here that the expression of the Hes5 and Mash1 genes, which encode neural-specific bHLH proteins, decrease and increase, respectively...

..., unlike Hes1 , which is expressed only by the former cells. Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription. In addition, Hes6 suppresses Hes1 from inhibiting Mash1-E47 heterodimer and thereby enables Mash1 and E47 to upregulate transcription in the presence of Hes1...

... are expressed with distinct patterns in the olfactory placodes and are subject to different regulatory mechanisms. Hes1 is expressed in a broad placodal domain, which is maintained in absence of the neural determination gene Mash1 . In contrast, expression of Hes5 is restricted to clusters of neural progenitor...

... crest lineage . Development 124 , 4351 – 4359 . 10.1242/dev.124.21.4351 Hirsch , M. R. , Tiveron , M. C. , Guillemot , F. , Brunet , J. F. and Goridis , C. ( 1998 ). Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central...

...Marie-Rose Hirsch; Marie-Catherine Tiveron; François Guillemot; Jean-François Brunet; Christo Goridis ABSTRACT Mash1 , a mammalian homologue of the Drosophila proneural genes of the achaete-scute complex, is transiently expressed throughout the developing peripheral autonomic nervous system...

...) with bone morphogenetic protein-2 (BMP-2) leads to an induction of MASH1 expression and consequent autonomic neuronal differentiation. We now show that BMP2 also induces expression of the paired homeodomain transcription factor Phox2a, and the GDNF/NTN signalling receptor tyrosine kinase c-RET. Constitutive...

... the isolation of a novel murine gene, Math4C/neurogenin1 , which is distantly related to the Drosophila proneural gene atonal . We show that Math4C/neurogenin1 and the basic helix-loop-helix gene Mash1 are expressed in the olfactory epithelium by different dividing progenitor populations, while another basic...