..., the mandible size considerably increases through two moltings (via the presoldier stage) under the control of juvenile hormone (JH). Regulatory genes are predicted to provide patterning information that induces the mandible-specific cell proliferation. To identify factors responsible for the mandibular...

... that patterns the mandible, maxilla and intervening hinge domain, but how the genes encoding these proteins are regulated remains unclear. Herein, we demonstrate that the concerted action of the AP-2α and AP-2β transcription factors within the mouse neural crest is essential for jaw patterning. In the absence...

...Wen Sun; Weiwei Sun; Jingning Liu; Xichao Zhou; Yongjun Xiao; Andrew Karaplis; Martin R. Pollak; Edward Brown; David Goltzman; Dengshun Miao To determine whether the calcium-sensing receptor (CaR) participates in tooth formation and dental alveolar bone development in mandibles in vivo, we examined...

... is largely unknown. Here, we report that Hand2 negatively regulates intramembranous ossification of the mandible by directly inhibiting the transcription factor Runx2, a master regulator of osteoblast differentiation. Hand proteins physically interact with Runx2, suppressing its DNA binding...

.... * Author for correspondence (e-mail: [email protected] ) 7 6 2004 © 2004. 2004 Mouse Bone Mandible Patterning Neural crest cell Homeobox gene Craniofacial morphogenesis is orchestrated through a specific array of transcription factors, expressed in both spatially...

... of the phenotype is dependent on the genetic background of a C57BL/6 (B6) strain; most of the offspring of Otx2 knock-out chimeras, which are equivalent to the F 1 of CBA and B6 strains, backcrossed with B6 females display reduction or loss of mandible, whereas those backcrossed with CBA females do not show...

... for the evolution of the unique Hemipteran head. * Author for correspondence (e-mail: [email protected] ) 20 06 2000 09 08 2000 © 2000 by Company of Biologists 2000 RNAi Hemiptera Milkweed bug Oncopeltus Head Stylate-haustellate mouthpart Mandible Maxilla Labium Hox...

... homeobox branchial arch mandible regulation mouse The distal-less family of homeobox genes contains six members, Dlx1, Dlx2, Dlx3, Dlx5, Dlx6 and Dlx7 , arranged in convergent pairs within the genome of mammals. Both genes of a given pair ( Dlx1 and Dlx2, Dlx3 and Dlx7, Dlx5 and 6...

... to epithelial signals such as Fgf8, indicating that there is no pre-specification of these cells into different populations and suggesting that patterning of the hard tissues of the mandible is instructed by the epithelium. By E10.5, ectomesenchymal cell gene expression domains are still dependent on epithelial...

... cells. The changes in competence of the first arch mesenchyme to respond to Fgf-8 are indicated schematically in Fig. 8B . This loss in competence coincides with the activation of Gsc expression in the caudal half of the mandible. Thus although Gsc does not act to define the initial rostral-caudal...

... not include the lining epithelium. 19 10 1992 © 1993 by Company of Biologists 1993 goosecoid gene expression branchial arches tongue ear mandible limb buds Work on Drosophila and vertebrate embryos has shown that morphogenesis and the development of pattern is often...

...Joy M. Richman; Zoe Crosby ABSTRACT Differential growth of the three major facial primordia, the frontonasal mass, maxilla and mandible, results in a characteristic face shape. Abnormal growth of any of the primordia can lead to facial defects. In order to dissect out the factors that control...