1-12 of 12
Keywords: Mandible
Close
Sort by
Journal Articles
Journal: Development
Development (2019) 146 (5): dev171942.
Published: 4 March 2019
..., the mandible size considerably increases through two moltings (via the presoldier stage) under the control of juvenile hormone (JH). Regulatory genes are predicted to provide patterning information that induces the mandible-specific cell proliferation. To identify factors responsible for the mandibular...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (2): dev157438.
Published: 25 January 2018
... that patterns the mandible, maxilla and intervening hinge domain, but how the genes encoding these proteins are regulated remains unclear. Herein, we demonstrate that the concerted action of the AP-2α and AP-2β transcription factors within the mouse neural crest is essential for jaw patterning. In the absence...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (4): 615–625.
Published: 15 February 2009
... is largely unknown. Here, we report that Hand2 negatively regulates intramembranous ossification of the mandible by directly inhibiting the transcription factor Runx2, a master regulator of osteoblast differentiation. Hand proteins physically interact with Runx2, suppressing its DNA binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4413–4423.
Published: 15 September 2004
..., we closely examined expression of Hand2, Dlx5 and Dlx6 in the developing mandible of Ednra –/– embryos. In contrast to the arch expression in wild-type embryos( Fig. 2M,O ), Dlx5 and Dlx6 expression in Ednra –/– embryos was downregulated throughout the mandibular arch mesenchyme( Fig...
Journal Articles
Journal: Development
Development (2002) 129 (18): 4347–4357.
Published: 15 September 2002
... of the phenotype is dependent on the genetic background of a C57BL/6 (B6) strain; most of the offspring of Otx2 knock-out chimeras, which are equivalent to the F 1 of CBA and B6 strains, backcrossed with B6 females display reduction or loss of mandible, whereas those backcrossed with CBA females do not show...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (2): 217–224.
Published: 15 January 2000
.... Schematic diagram demonstrating the regulation of Dlx2 by FGF8 and BMP4 in the mandible at E10.5. BMP4 (red) is expressed in the epithelium of the distal region of the mandible. It induces Dlx2 in the epithelium (blue shading) via an intra-epithelial signal. FGF8 (green) is expressed in the epithelium...
Journal Articles
Journal: Development
Development (2000) 127 (2): 403–412.
Published: 15 January 2000
... to epithelial signals such as Fgf8, indicating that there is no pre-specification of these cells into different populations and suggesting that patterning of the hard tissues of the mandible is instructed by the epithelium. By E10.5, ectomesenchymal cell gene expression domains are still dependent on epithelial...
Journal Articles
Journal: Development
Development (1999) 126 (1): 51–61.
Published: 1 January 1999
... Mandible Lim homeobox Fgf-8 Goosecoid Mouse Cell signalling The establishment of pattern during embryogenesis involves the cellular and molecular division of cells to provide ‘positional information’. Branchial arches give rise to a wide range of structures specific to each arch. Thus each...
Journal Articles
Journal Articles