...Bethan Lloyd-Lewis; Felicity M. Davis; Olivia B. Harris; Jessica R. Hitchcock; Christine J. Watson ABSTRACT Mammary gland development occurs over multiple phases, beginning in the mammalian embryo and continuing throughout reproductive life. The remarkable morphogenetic capacity of the mammary...

... a crucial noncircadian function of PER2 in mammalian mammary gland development, validates the Per2 −/− model, and describes a potential role for PER2 in breast cancer. Author contributions Conceptualization: W.W.P.; Methodology: C.M.M., E.E.S., R.P.M., D.E., W.W.P.; Validation: C.M.M., E.E.S...

... AKT or mTOR. Mammary gland development Lgr5 Mammary stem cells Basal cells Luminal cells mTOR signaling CBLB Casitas B-lineage lymphoma Mouse Postnatal organ development and maintenance require organ-resident stem cells. While mechanisms of hematopoietic stem cell (HSC...

..., it remains unclear what genes maintain MaSCs and control their specification into the two epithelial lineages: luminal and basal. LBH is a novel transcription co-factor in the WNT pathway with hitherto unknown physiological function. LBH is expressed during mammary gland development and aberrantly...

... these processes in vivo . Here, we demonstrate that Polo-like kinase 2 (Plk2) regulates mitotic spindle orientation in the mammary gland and that this might account for its suggested role as a tumor suppressor. Plk2 is highly expressed in the mammary gland and is required for proper mammary gland development...

... in human breast tumors. However, the role of MTA1 in tumorigenesis in a physiologically relevant animal system remains unknown. To reveal the role of MTA1 in mammary gland development, transgenic mice expressing MTA1 under the control of the mouse mammary tumor virus promoter long terminal repeat were...

... Differentiation ERBB Lactation Mammary gland development STAT5 Tissue specific gene deletion Mouse The majority of mammary gland development occurs postnatally, and is regulated during adulthood through the complex and coordinated activities of systemic hormones and locally synthesized growth...

...Glendon Zinser; Kathryn Packman; JoEllen Welsh Postnatal mammary gland morphogenesis is achieved through coordination of signaling networks in both the epithelial and stromal cells of the developing gland. While the major proliferative hormones driving pubertal mammary gland development...