... and is in line with prior anecdotal evidence that mammary development essentially fails altogether in the absence of p120 ( Davis and Reynolds, 2006 ). Given the unique morphogenetic status of the TEB, it will be interesting to extend these studies to p120 KO in breast cancer models as well as fully developed...

... proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cells and in a subset of luminal epithelial cells, and that its targeted deletion impairs ductal expansion...

..., it was interesting to determine if the absence of LIF had consequences for postnatal mammary development. In Lif -;/-; mammary glands as early as 4 weeks of age, ductal elongation was markedly reduced and the ducts were thicker( Fig. 4C ). In addition to a reduction in growth rate in the absence of LIF...

.... and Hennighausen, L. ( 2001 ). Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J. Cell Biol . 155 , 531 -542. Muller, W. J. and Neville, M. C. ( 2001 ). Introduction: Signaling in mammary development...

... in the epithelial cells of the mammary bud and, during embryonic mammary development, it interacts with the surrounding mesenchymal cells to induce the formation of the dense mammary mesenchyme. In response, these mammary-specific mesenchymal cells support the maintenance of mammary epithelial cell fate, trigger...

... signalling in the adult mammary gland in vivo. * Author for correspondence (e-mail: [email protected] ) 02 05 1997 © 1997 by Company of Biologists 1997 mammary development ductal growth lactogenesis mammary stroma mouse transforming growth factor βB...