... envelope during spermatogenesis is required to ensure the integrity of sperm for capacitation and fertilization. Here, we report that Arrdc5 is associated with spermatogenesis. The Arrdc5 knockout mouse model showed male infertility characterized by a high bent-head rate and reduced motility in sperm...

... causes male infertility with morphological and motility defects in spermatozoa. Owing to the lack of CCDC183, centrioles after elongation of axonemal microtubules do not connect the cell surface and nucleus during spermiogenesis, which causes subsequent loss of cytoplasmic invagination around...

.../15472 Houston , B. J. , Conrad , D. F. and O'Bryan , M. K. (2021). A framework for high-resolution phenotyping of candidate male infertility mutants: from human to mouse . Hum. Genet. 140 , 155 - 182 . 10.1007/s00439-020-02159-x Hu , W. F. , Pomp , O. , Ben...

... proteins, and ACTRT1 in the acroplaxome anchors developing acrosomes to the sperm nucleus. Sperm Perinuclear theca Actin-related protein Detached acrosome Male infertility National Key Research and Development Program of China 2019YFA0802101 Fundamental Research Funds...

... series of KATNB1 loss-of-function models reveals that katanin proteins are required to regulate the vast majority of microtubule-based processes in male germ cell development. Male fertility Male infertility Microtubules Spermiogenesis Acrosome Axoneme Meiotic spindle Microtubule severing...

..., and the distribution of intraflagellar transport proteins is disrupted. This study reveals an organ-specific mechanism of axoneme stabilization that is related to male infertility. * These authors contributed equally to this work ‡ Authors for correspondence ([email protected] ; [email protected]...

... 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary:  RNA sequencing and proteomics analyses of Fsip2 transgenic mouse models reveal insights into the role of Fsip2 in sperm tail and acrosome formation, which may be crucial for fertility. FSIP2 Male infertility...

... the epidermal mucociliary epithelium was reduced. Likewise, Cfap206 knockout mice revealed ciliary phenotypes. Electron tomography of immotile knockout mouse sperm flagella indicated a role in radial spoke formation reminiscent of FAP206 function in Tetrahymena . Male infertility, hydrocephalus and impaired...

... has requirements that differ from other motile cilia. This presumption is supported by mutations of other ciliogenesis factors that distinctly affect sperm cells: e.g. disruption of Spef2 causes disorganised flagellar axonemes and male infertility but normal tracheal axonemes (Sironen et al., 2011...

... with sperm from germline-specific Dicer or Drosha conditional knockout mice is impaired, highlighting key roles for paternal miRNAs/endo-siRNAs. Sperm Small noncoding RNAs Male infertility Embryonic development Assisted reproductive technologies Maternal transcripts In vitro fertilization...