..., and for the proper functioning and aging of hematopoietic stem and progenitor cells (HSPCs) in mice. Here, we have found that, in zebrafish development, Trim33 is essential cell-autonomously for the lifespan of the yolk sac-derived primitive macrophages, as well as for the initial production of definitive (HSPC...

... cells to carry out functions during tissue repair and homeostasis. Stem cells Regeneration Innate immunity Trained immunity Macrophages Hemocytes Homeostasis National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM132753 University...

... of signals that influence regenerative neurogenesis in the central nervous system of zebrafish, indicating possible avenues for activation of similar signalling pathways in non-regenerating mammals. Müller cells Cytokines Ependymo-radial glia Macrophages Neurotransmitters Radial glia...

...Andrea L. Bredemeyer; Junedh M. Amrute; Andrew L. Koenig; Rachel A. Idol; Li He; Stephanie A. Luff; Carissa Dege; Jamison M. Leid; Joel D. Schilling; J. Travis Hinson; Mary C. Dinauer; Christopher M. Sturgeon; Kory J. Lavine ABSTRACT Tissue-resident macrophages are increasingly recognized...

...Laina Freyer; Yvan Lallemand; Pascal Dardenne; Alina Sommer; Anne Biton; Elisa Gomez Perdiguero ABSTRACT Hofbauer cells (HBCs) are tissue macrophages of the placenta thought to be important for fetoplacental vascular development and innate immune protection. The developmental origins of HBCs remain...

..., in contrast to the limited regenerative abilities of human tissues. Following cricket leg amputation, the wound surface is covered by the wound epidermis, and plasmatocytes, which are insect macrophages, accumulate in the wound region. Here, we studied the function of Toll-related molecules identified...

... ABSTRACT Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized their identity, ontogeny and function during heart development. Here, we show...

...Giuliano Ferrero; Magali Miserocchi; Elodie Di Ruggiero; Valérie Wittamer ABSTRACT In vertebrates, the ontogeny of microglia, the resident macrophages of the central nervous system, initiates early during development from primitive macrophages. Although murine embryonic microglia then persist...

.... Summary:   Xenopus tail regeneration requires a hierarchy of cellular events initiated by the myeloid lineage and culminating in the mobilization of regeneration-organizing cells. Xenopus Tail regeneration Myeloid lineage Inflammation Macrophages Neutrophils University of Cambridge...

... -reporter genes were specifically expressed at high levels in cells of the macrophage lineage and at a much lower level in granulocytes. The cell lineage specificity of reporter gene expression was confirmed by demonstration of coincident expression with the endogenous CSF1R protein. In transgenic birds...

...Timothy A. Petrie; Nicholas S. Strand; Chao Tsung-Yang; Jeremy S. Rabinowitz; Randall T. Moon Neutrophils and macrophages, as key mediators of inflammation, have defined functionally important roles in mammalian tissue repair. Although recent evidence suggests that similar cells exist in zebrafish...

..., the trachea, the wing and in macrophages. knittrig mutants exhibit mild tracheal defects but survive until late pupal stages and mainly die as pharate adult flies. knittrig mutant macrophages are smaller and show reduced cell spreading and cell migration in in vivo wounding experiments. Rescue experiments...

...Emma J. Gordon; Sujata Rao; Jeffrey W. Pollard; Stephen L. Nutt; Richard A. Lang; Natasha L. Harvey Macrophages have been suggested to stimulate neo-lymphangiogenesis in settings of inflammation via two potential mechanisms: (1) acting as a source of lymphatic endothelial progenitor cells via...

..., these animals are distinguished by an excessive lysosomal storage in macrophages of the liver, spleen, bone marrow, kidney and by altered growth plates. Microscopic analyses showed an accumulation of osteopontin adjacent to actively resorbing osteoclasts of Acp5- and LAP/Acp5-deficient mice. In osteoclasts...

... and cleared by macrophages. We show that in a macrophageless mouse embryo, null for the haemopoetic-lineage-specific transcription factor, PU.1, the task of phagocytosis is taken over by ‘stand-in’ mesenchymal neighbours in a clear example of cell redundancy. However, it takes three times as many...

...Ulrich Tepass; Liselotte I. Fessler; Amina Aziz; Volker Hartenstein ABSTRACT We have studied the embryonic development of Drosophila hemocytes and their conversion into macrophages. Hemocytes derive exclusively from the mesoderm of the head and disperse along several invariant migratory paths...

..., the postnatal development of cells bearing the macrophage marker antigens F4/80 and MOMA-1, in op/op mice and their normal (+/ op or +/+) littermates, were studied during the first three months of life. In normal mice, maximum expression of tissue F4/80+ cells was generally correlated with the period of maximum...

... by macrophages. Programmed cell deaths can be rapidly and reliably visualized in living wild-type and mutant Drosophila embryos using the vital dyes acridine orange or nile blue. Acridine orange appears to selectively stain apoptotic forms of death in these preparations, since cells undergoing necrotic deaths...

... in the mesen-chyme and also appeared within some organ primordia such as the neural tube, the liver anlage and the nephric rudiment. Comparison of the results in the two types of chimeras and the findings obtained with acid phosphatase/MB1 double labelling showed that some hemopoietic macrophage-like cells...