... Maternal to zygotic transition MZT Mid-blastula transition MBT Zygotic genome activation ZGA Nuclear cytoplasmic ratio Cell cycle Princeton University http://dx.doi.org/10.13039/100006734 Upon fertilization the embryo must produce enough cells to pattern a functioning organism...

...Nadine L. Vastenhouw; Wen Xi Cao; Howard D. Lipshitz ABSTRACT The development of animal embryos is initially directed by maternal gene products. Then, during the maternal-to-zygotic transition (MZT), developmental control is handed to the zygotic genome. Extensive research in both vertebrate...

... is necessary for yolk syncytial layer development but is not directly required for embryonic cell differentiation. Nanog Zebrafish Maternal-to-zygotic transition MZT Yolk syncytial layer YSL Zygotic genome activation ZGA Lineage tracing GESTALT American Cancer Society 10.13039...

... of miRNAs during the earliest stage of Drosophila development, when the maternal-to-zygotic transition (MZT) takes place. Eleven miRNA clusters comprise the first set of miRNAs activated in the blastoderm embryo. The transcriptional activator Zelda is required for their proper activation and regulation...

... attributed. MZT Maternal Paternal Transcriptome Zebrafish During the earliest steps of embryonic development there are dramatic changes in transcriptional dynamics. Initially, development proceeds in the absence of de novo transcription and depends on maternal mRNAs and proteins...