... evolutionary conservation are incompletely understood. In C. elegans , a sperm-sensing mechanism regulates oocyte meiotic maturation and ovulation, tightly coordinating sperm availability and fertilization. Sperm release the major sperm protein (MSP)signal to trigger meiotic resumption (meiotic maturation...

... versus meiotic entry decision. Thus, two major germline signaling centers, distal GLP-1 activation and proximal MSP signaling,coordinate several spatially and temporally distinct processes by which germline stem cells differentiate into functional oocytes. † Author for correspondence (e...