.... This study contrasts KMT2D and UTX neural crest differentiation function as sources of variation in facial gestalt for Kabuki syndrome. KMT2D MLL4 Kabuki syndrome Histone methylation Neural crest Craniofacial Epigenetics play a vital role in facial development, as mutations in chromatin...

... of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling. KMT2D MLL2 MLL4 ALR Kabuki syndrome H3K4 methylation Heart development Mouse During heart development genes are tightly regulated to ensure expression in specific cardiac tissues at the appropriate...