...Jovica Ninkovic; Alexandra Tallafuss; Christoph Leucht; Jacek Topczewski; Birgit Tannhäuser; Lilianna Solnica-Krezel; Laure Bally-Cuif The intervening zone (IZ) is a pool of progenitor cells located at the midbrain-hindbrain boundary (MHB) and important for MHB maintenance,midbrain-hindbrain...

...Tokiharu Takahashi; Peter W. H. Holland The ancestral chordate neural tube had a tripartite structure, comprising anterior, midbrain-hindbrain boundary (MHB) and posterior regions. The most anterior region encompasses both forebrain and midbrain in vertebrates. It is not clear when or how...

...Yuji Watanabe; Reiko Toyoda; Harukazu Nakamura Trochlear motor axons project dorsally along the midbrain-hindbrain boundary (MHB) to decussate at the dorsal midline. We report on the roles of neuropilin 2 and its ligands in the molecular mechanisms controlling this trajectory. In chick embryos...

...József Jászai; Frank Reifers; Alexander Picker; Tobias Langenberg; Michael Brand In zebrafish acerebellar ( ace ) embryos, because of a point mutation in fgf8 , the isthmic constriction containing the midbrain-hindbrain boundary (MHB) organizer fails to form. The mutants lack cerebellar...

... a neuron-free zone (`intervening zone', IZ) at the midbrain-hindbrain boundary(MHB). The mechanisms establishing this early pattern of neurogenesis are unknown. We demonstrate that the MHB is globally refractory to neurogenesis,and that forced neurogenesis in this area interferes with the continued...

... experiments in zebrafish, we have isolated mutations that cause abnormal hindbrain organization and a failure of the midbrain-hindbrain boundary (MHB) to form, a region that acts as an organizer for the adjacent brain regions. The mutations fail to complement the spiel-ohne-grenzen ( spg ) mutation, which...

...Gerlinde Reim; Michael Brand Neural patterning of the vertebrate brain starts within the ectoderm during gastrulation and requires the activity of organizer cell populations in the neurectoderm. One such organizer is located at the prospective midbrain-hindbrain boundary (MHB) and controls...

...Heinz-Georg Belting; Giselbert Hauptmann; Dirk Meyer; Salim Abdelilah-Seyfried; Ajay Chitnis; Cathrin Eschbach; Iris Söll; Christine Thisse; Bernard Thisse; Kristin B. Artinger; Karen Lunde; Wolfgang Driever The vertebrate midbrain-hindbrain boundary (MHB) organizes patterning and neuronal...

...Matthias Carl; Joachim Wittbrodt Signalling by fibroblast growth factors (FGFs) at the mid-hindbrain boundary (MHB) is of central importance for anteroposterior neural patterning from the isthmic organiser. Graded suppression of FGF signalling by increasing amounts of a dominant negative FGF...