... gene expression in sea urchin embryos. Using this approach, we explored the roles the MAPK signaling plays in skeletogenesis by expressing genes that perturb the pathway specifically in primary mesenchyme cells during later stages of development. We demonstrated the wide utility of the Tet-On system...

... of growth factors. This perspective is consistent with the frequent activation of MAPK signaling in cancer ( Whyte et al., 2009 ) and suggests that high MAPK activity might be sufficient to initiate collective cell invasion during metastasis. It will be crucial for future studies to elucidate...