... of the schizophrenia-associated gene Disc1 in the developing mouse and in vitro leads to impaired astrogenesis due to disrupted RAS/ERK signaling. DISC1 Astrogenesis RAS/MEK/ERK signaling MAP kinase RASSF7 Cortical development National Basic Research Program of China 10.13039/501100002855...

... the activation of the intracellular signaling pathways downstream of LIF in ESCs with different genetic backgrounds. We found that the JAK-Stat3 pathway was dominantly activated in ESCs derived from ‘permissive’ mouse strains (129Sv and C57BL6), whereas the MAP kinase pathway was hyperactivated in ESCs from ‘non...

... is a target of MAP kinase in the sevenless signal transduction pathway . Nature 370 , 386 – 389 . Casci T. , Vinós J. , Freeman M. ( 1999 ). Sprouty, an intracellular inhibitor of Ras signaling . Cell 96 , 655 – 665 . Cavallo R. A. , Cox R. T. , Moline M. M...

.... The inability to derive embryonic stem (ES) cell lines in a variety of species suggests divergence between species in the cell signaling pathways involved in early lineage specification. In mouse, segregation of the primitive endoderm lineage from the pluripotent epiblast lineage depends on FGF/MAP kinase...

... Heidelberg, Germany 16 3 2009 © 2009. 2009 Cell cycle Cyclin Fertilization MAP kinase p90Rsk Starfish eggs The transition from oocyte to embryo is essential for initiating embryonic development. A key event in this transition is the start of the embryonic mitotic...

... address: Salk Institute for Biological Studies, PBL-M, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA † Present address: INSERM, U784, 46, Rue d'Ulm, 75230 Paris Cedex 05,France 31 3 2008 © 2008. 2008 ESCRT complex MAP kinase HD-PTP (PTPN23) Bro1 domain Photoreceptor...

... stages before compaction have remained unclear. Here, we show that extracellular signal regulated kinase (ERK) mitogen-activated protein (MAP) kinase function is required for early embryonic cell division before compaction. Our analysis demonstrates that inhibition of ERK activation in late two-cell...

...Eric Röttinger; Jenifer Croce; Guy Lhomond; Lydia Besnardeau; Christian Gache; Thierry Lepage Studies in Caenorhabditis elegans and vertebrates have established that the MAP kinase-related protein NLK counteracts Wnt signalling by downregulating the transcription factor TCF. Here, we present...

...-mail: [email protected] ) * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Germany 31 3 2006 © 2006. 2006 Endoderm Zebrafish FGF BMP MAP kinase Mesoderm Casanova Bon ERK In the zebrafish...

... activation and entry into M-phase in cycling Xenopus egg extracts. Mol. Biol. Cell 9 , 451 -467. Carroll, D. J., Albay, D. T., Hoang, K. M., O'Neill, F. J.,Kumano, M. and Foltz, K. R. ( 2000 ). The relationship between calcium, MAP kinase, and DNA synthesis in the sea urchin egg at fertilization...

...: Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA 17 2 2006 © 2006. 2006 Drosophila moleskin Importin 7 Morphogenetic furrow MAP kinase Cell cycle Nuclear translocation ERK Hedgehog Dpp Egfr...

.... ( 2000 ). Drawing lines in the Drosophila wing: initiation of wing vein development. Curr. Opin. Genet. Dev. 10 , 393 -398. Biggs, W. H. r., Zavitz, K. H., Dickson, B., van der Straten,A., Brunner, D., Hafen, E. and Zipursky, S. L. ( 1994 ). The Drosophila rolled locus encodes a MAP kinase...

... of the intestinal nuclei is unchanged in the sma-5 mutant. The sma-5 gene is expressed in intestine,excretory cell and hypodermis, and encodes homologs of a mammalian MAP kinase BMK1/ERK5/MAPK7, which was reported to control cell cycle and cell proliferation. Expression of the sma-5 gene in hypodermis is important...

... or MII arrest, even when fertilization does not occur. Here we show that MI arrest of starfish oocytes occurs in the ovary after germinal vesicle breakdown. This arrest is maintained both by the Mos/MEK/MAP kinase pathway and the blockage of an increase of intracellular pH in the ovary before spawning...

... of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA 23 4 2003 © 2003. 2003 MAP kinase Drosophila Compound eye The Drosophila compound eye is composed of about 800 similar facets or ommatidia, each of which contains eight photoreceptor and 12...

..., but integration is likely to be achieved at least partly by cytoplasmic signal transduction networks. Work in other systems ( Drosophila tracheae, MDCK models) suggests that the mitogen-activated protein (MAP) kinase pathway might be important to epithelial branching. We have investigated the role of the MAP...

...James A. Lorenzen; Scott E. Baker; Fabienne Denhez; Michael B. Melnick; Danny L. Brower; Lizabeth A. Perkins ABSTRACT The initiation of gene expression in response to Drosophila receptor tyrosine kinase signaling requires the nuclear import of the MAP kinase, D-ERK. However, the molecular details...

... signalling pathway downstream of Ras and in parallel to the extracellular signal-regulated kinase (ERK) MAP kinases. In addition, our results show that ERKs and PI3Ks can synergise to convert ectoderm into mesoderm. These data provide the first evidence that class 1 PI3Ks are required for a specific set...

... this cell fate choice. * Author for correspondence (e-mail: [email protected] ) 20 06 2000 09 08 2000 © 2000 by Company of Biologists 2000 Limb Cell fate Cross-talk MAD MAP kinase Drosophila It has been shown that development of insect wings and legs...

..., the calcium oscillations also continue indefinitely. Finally, in oocytes that contain low mitogen- activated protein (MAP) kinase activity and elevated CDK activity, the sperm-triggered calcium oscillations are again prolonged. We conclude that the CDK activity of the ascidian oocyte can be regarded...