... of these processes could lead to disease, including cancer. We have examined the function of the sole C. elegans SoxC protein, SEM-2, in the M lineage, which produces the postembryonic mesoderm. We found that SEM-2/SoxC is both necessary and sufficient to promote a proliferating blast cell fate, the sex myoblast...

...-receptor Body size Mesoderm M lineage C. elegans Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily of ligands and the BMP signaling pathway plays roles in multiple developmental and homeostatic processes ( Wu and Hill, 2009 ). Malfunction...

... at 37°C for one hour followed by recovery at 20°C for three hours until the majority of animals reached the 18-M stage. Non-heat-shocked animals were used as controls. Animals were scored during subsequent larval development for the number and type of M lineage-derived cells. Plasmid pNMA70...

.... We show that FOZI-1 shares the same expression pattern as CeMyoD in the postembryonic mesodermal lineage, the M lineage, and that fozi-1 -null mutants exhibit similar M lineage-null defects to those found in animals lacking CeMyoD in the M lineage (e.g. loss of a fraction of M lineage-derived BWMs...

... as a downstream component to mediate the Sma/Mab TGFβ signaling pathway in these processes. We have discovered a new role for SMA-9 in dorsoventral patterning of the C. elegans post-embryonic mesoderm, the M lineage. In addition to a small body size, sma-9 mutant animals exhibit a dorsal-to-ventral fate...

... differentiation M lineage Myoblast SM Sex muscles The development of functional muscles involves a series of distinct biological events, including fate specification, migration, proliferation and differentiation. Extensive analyses have demonstrated that these processes are highly regulated...

... several differences at the cellular and molecular levels during vulval formation. For example, the mesoblast M participates in lateral inhibition, a process that influences the fate of two vulval precursor cells. Here, we describe the M lineage in Pristionchus and show that both the dorsal and ventral M...