... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...

...Yuji Atsuta; Yoshiko Takahashi The Müllerian duct (MD) and Wolffian duct (WD) are embryonic tubular tissues giving rise to female and male reproductive tracts, respectively. In amniote embryos, both MD and WD emerge in both sexes, but subsequently degenerate in the males and females, respectively...

... both the mesonephric tubules and WD (Sainio et al., 1997). These tubules and the cranial aspect (white arrow) of the WD were both missing in mutant mice at E11.5 (Fig. 3A,B). Lhx1 is also normally expressed in these tissues and in the Müllerian duct (Fujii et al., 1994 ; Karavanov et al., 1998...

... ducts have differentiated and the testes have migrated through the inguinal canal. Female tammars treated with testosterone propionate (24-50 mg kg −1 day −1) orally for 25 days had enlarged Wolffian and Müllerian ducts. Mammary and pouch development, however, was indistinguishable from that of control...