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Keywords: Lymphovenous valves
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Journal Articles

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling

Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J. Randolph, Xinwei Cao, Hong Chen, R. Sathish Srinivasan
Journal: Development
Development (2020) 147 (23): dev195453.
https://doi.org/10.1242/dev.195453
Published: 13 December 2020
... factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and vascular endothelial growth factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor...
View article titled, YAP and TAZ maintain PROX1 expression in the developing lymphatic and <span class="search-highlight">lymphovenous</span> <span class="search-highlight">valves</span> in response to VEGF-C signaling
Open the PDF for YAP and TAZ maintain PROX1 expression in the developing lymphatic and <span class="search-highlight">lymphovenous</span> <span class="search-highlight">valves</span> in response to VEGF-C signaling in another window
Includes: Supplementary data
Journal Articles

RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice

Di Chen, Xin Geng, Philip E. Lapinski, Michael J. Davis, R. Sathish Srinivasan, Philip D. King
Journal: Development
Development (2020) 147 (23): dev192351.
https://doi.org/10.1242/dev.192351
Published: 7 December 2020
... and maintenance of lymphovenous valves (LVV) and venous valves (VV) is unknown. In this study, we show that induced disruption of Rasa1 in mouse embryos did not affect initial specification of LVV or central VV, but did affect their continued development. Similarly, a switch to expression of a catalytically...
View article titled, RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice
Open the PDF for RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice in another window
Includes: Supplementary data
Journal Articles

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma, Lijuan Chen, Greggory Myers, Sally Camper, Debbie Mustacich, Marlys Witte, Dongwon Choi, Young-Kwon Hong, Hong Chen, Gaurav Varshney, James Douglas Engel, Shusheng Wang, Tae-Hoon Kim, Kim-Chew Lim, R. Sathish Srinivasan
Journal: Development
Development (2019) 146 (21): dev184218.
https://doi.org/10.1242/dev.184218
Published: 5 November 2019
... ABSTRACT Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead...
View article titled, GATA2 controls lymphatic endothelial cell junctional integrity and <span class="search-highlight">lymphovenous</span> <span class="search-highlight">valve</span> morphogenesis through miR-126
Open the PDF for GATA2 controls lymphatic endothelial cell junctional integrity and <span class="search-highlight">lymphovenous</span> <span class="search-highlight">valve</span> morphogenesis through miR-126 in another window
Includes: Supplementary data