... is essential for the HSC generation and, therefore, all derivatives lineages. Using mouse embryonic stem cells (mESCs) to recapitulate murine embryonic development, we have studied the requirement for Notch signaling during the earliest B-cell lymphopoiesis and found that Rbpj -deficient mESCs are able...

... by Company of Biologists 1993 ES cells lymphopoiesis repopulation Murine hematopoiesis begins by day 7 of embryogenesis and proceeds throughout the entire life span of the animal to provide at least eight distinct lineages of mature blood cells. All of these cells, which differ...