... of specialized lymphatic endothelial cells (LECs) and their subsequent assembly in primary lymphatic vessels. Although lymphatic cells are in continuous contact with mesenchymal cells during development and in adult tissues, the role of mesenchymal cells in lymphatic vasculature development remains poorly...

... of vascular morphogenesis. Lymphatic vasculature Lymphovenous valves GATA2 miR-126 Claudin 5 VE-cadherin The lymphatic vasculature is a hierarchically organized tissue that absorbs and returns extravasated plasma fluids and digested lipids to the blood circulation ( Chen et al., 2014...

..., we reveal that expression of Pdgfb within the developing dermal lymphatic vasculature is restricted to LECs of collecting vessels but absent from capillaries. Using conditional loss- and gain-of-function models, we show that LEC expression of PDGFB is required for SMC recruitment to collecting...

... interactions with neighbouring tissues and control vessel maturation are beginning to emerge. Here, we review the most recent advances in lymphatic vascular development, with a major focus on mouse and zebrafish model systems. By E14.5 in the mouse, the lymphatic vasculature has extended throughout...