.../user-licence-1-1/ Summary: Peripheral nerve-derived CXCL12 signals through its receptor CXCR4 in lymphatic endothelial cells to regulate lymphatic sprouting and patterning. CXCL12/CXCR4 Peripheral nerves VEGFC/VEGFR3 Lymphangiogenesis Lymphatic development Chemokine signaling...

... migration and proliferation, and in lymphatic specification during early lymphangiogenesis, at least in part by modulating Vegfc/Vegfr3 signaling. Thus, we show that Angpt1/Tie1 signaling constitutes an essential signaling pathway for lymphatic development in zebrafish. * These authors contributed...

...Denver D. Britto; Jia He; June P. Misa; Wenxuan Chen; Purvi M. Kakadia; Lin Grimm; Caitlin D. Herbert; Kathryn E. Crosier; Philip S. Crosier; Stefan K. Bohlander; Benjamin M. Hogan; Christopher J. Hall; Jesús Torres-Vázquez; Jonathan W. Astin ABSTRACT Lymphangiogenesis is a dynamic process...

... and heterogeneity, and discovery of novel genes and signalling pathways underpinning developmental lymphangiogenesis. Here, we review these advances and discuss how they inform our understanding of lymphatic network formation, function and dysfunction. * Authors for correspondence ( [email protected]...

... , N. C. , Duckers , H. J. and Schulte-Merker , S. ( 2009a ). Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting . Nat. Genet. 41 , 396 - 398 . 10.1038/ng.321 Hogan , B. M. , Herpers , R. , Witte , M. , Heloterä , H. , Alitalo , K...

...) first sprouts from cardinal veins followed by migration and proliferation to colonise embryonic tissues. Although much is known about the molecular regulation of LEC fate and sprouting during early lymphangiogenesis, we know far less about the instructive and permissive signals that support LEC...

...Kenta Niimi; Misaki Kohara; Eriko Sedoh; Moe Fukumoto; Satoshi Shibata; Toshinori Sawano; Fumi Tashiro; Satsuki Miyazaki; Yoshiaki Kubota; Jun-ichi Miyazaki; Shinobu Inagaki; Tatsuo Furuyama ABSTRACT Lymphangiogenesis plays important roles in normal fetal development and postnatal growth. However...

... of whether a similar mechanism operates during pathological lymphangiogenesis. * Present address: Princess Máxima Center for Pediatric Oncology, Utrecht 3584CT, The Netherlands. ‡ These authors contributed equally to this work § Authors for correspondence ( [email protected]...

...Neil I. Bower; Adam J. Vogrin; Ludovic Le Guen; Huijun Chen; Steven A. Stacker; Marc G. Achen; Benjamin M. Hogan ABSTRACT Vascular endothelial growth factors (VEGFs) control angiogenesis and lymphangiogenesis during development and in pathological conditions. In the zebrafish trunk, Vegfa controls...

...Jonathan W. Astin; Michael J. L. Haggerty; Kazuhide S. Okuda; Ludovic Le Guen; June P. Misa; Alisha Tromp; Benjamin M. Hogan; Kathryn E. Crosier; Philip S. Crosier Lymphangiogenesis is a dynamic process that involves the sprouting of lymphatic endothelial cells (LECs) from veins to form lymphatic...

... restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequisite for the initiation of lymphangiogenesis. Murine Prox1 -null embryos lack lymphatic structures, and sustained expression of Prox1 is indispensable for the maintenance...

...Ludovic Le Guen; Terhi Karpanen; Dörte Schulte; Nicole C. Harris; Katarzyna Koltowska; Guy Roukens; Neil I. Bower; Andreas van Impel; Steven A. Stacker; Marc G. Achen; Stefan Schulte-Merker; Benjamin M. Hogan The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation...

...Emma J. Gordon; Sujata Rao; Jeffrey W. Pollard; Stephen L. Nutt; Richard A. Lang; Natasha L. Harvey Macrophages have been suggested to stimulate neo-lymphangiogenesis in settings of inflammation via two potential mechanisms: (1) acting as a source of lymphatic endothelial progenitor cells via...

... development, and also provide a novel aspect of VEGFR3 signalling modulated by Ras in lymphangiogenesis. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 19 1 2010 © 2010. 2010 Ras...

... ). Lymphangiogenesis in development and human disease . Nature 438 , 946 - 953 . Bando H. , Brokelmann M. , Toi M. , Alitalo K. , Sleeman J. P. , Sipos B. , Grone H.-J. , Weich H. A. ( 2004 ). Immunodetection and quantification of vascular endothelial growth factor...

... 2009. 2009 Genetic modifier Sox genes Prox1 Lymphangiogenesis HLT syndrome Mouse The expression of different phenotypes caused by the same mutation is commonly attributed to genetic modifiers( Nadeau, 2001 ). Modifier genes represent an important but poorly understood component...

... © 2009. 2009 Mouse PLCγ2 Lymphangiogenesis Vascular separation Bone marrow-derived cells Endothelial cell The lymphatic vasculature originates from the blood vasculature during development. Previous studies have demonstrated that the differentiation of lymphatic endothelial cells...

... angiogenesis and lymphangiogenesis. Accordingly, the specific knockdown of Xc-Myc provokes massive embryonic edema and hemorrhage. Conversely, Xc-Myc overexpression triggers the formation of ectopic vascular beds in embryos. Myc is required for normal expression of Slug/Snail2 and Twist , and either XSlug...

...-mail: [email protected] ) 11 7 2002 © 2002. 2002 Endothelial cell Growth factor receptor Lymphangiogenesis Mouse The vertebrate vascular system is composed of arteries, veins and capillaries, and develops early in embryonic development in order to accommodate the output...