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Keywords: Lymphangiogenesis
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Journal Articles
Journal: Development
Development (2021) 148 (4): dev194993.
Published: 19 February 2021
... zebrafish trunk. Lymphangiogenesis Vash1 Microtubules Tubulin detyrosination Sprouting angiogenesis Blood vessel formation and patterning is essential for tissue growth and homeostasis in vertebrate development and physiology. Endothelial cells (EC) arising from the lateral plate mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev190983.
Published: 18 September 2020
...) first sprouts from cardinal veins followed by migration and proliferation to colonise embryonic tissues. Although much is known about the molecular regulation of LEC fate and sprouting during early lymphangiogenesis, we know far less about the instructive and permissive signals that support LEC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181545.
Published: 17 January 2020
...Kenta Niimi; Misaki Kohara; Eriko Sedoh; Moe Fukumoto; Satoshi Shibata; Toshinori Sawano; Fumi Tashiro; Satsuki Miyazaki; Yoshiaki Kubota; Jun-ichi Miyazaki; Shinobu Inagaki; Tatsuo Furuyama ABSTRACT Lymphangiogenesis plays important roles in normal fetal development and postnatal growth. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
..., raising the question of whether a similar mechanism operates during pathological lymphangiogenesis. Highlighted Article: Genetic lineage tracing and targeted gene disruption and gain of function identify a novel source of lymphatic endothelial progenitors that contribute to the formation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 507–518.
Published: 01 February 2017
...Neil I. Bower; Adam J. Vogrin; Ludovic Le Guen; Huijun Chen; Steven A. Stacker; Marc G. Achen; Benjamin M. Hogan ABSTRACT Vascular endothelial growth factors (VEGFs) control angiogenesis and lymphangiogenesis during development and in pathological conditions. In the zebrafish trunk, Vegfa controls...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2680–2690.
Published: 01 July 2014
...Jonathan W. Astin; Michael J. L. Haggerty; Kazuhide S. Okuda; Ludovic Le Guen; June P. Misa; Alisha Tromp; Benjamin M. Hogan; Kathryn E. Crosier; Philip S. Crosier Lymphangiogenesis is a dynamic process that involves the sprouting of lymphatic endothelial cells (LECs) from veins to form lymphatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1228–1238.
Published: 15 March 2014
... restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequisite for the initiation of lymphangiogenesis. Murine Prox1 -null embryos lack lymphatic structures, and sustained expression of Prox1 is indispensable for the maintenance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1239–1249.
Published: 15 March 2014
...Ludovic Le Guen; Terhi Karpanen; Dörte Schulte; Nicole C. Harris; Katarzyna Koltowska; Guy Roukens; Neil I. Bower; Andreas van Impel; Steven A. Stacker; Marc G. Achen; Stefan Schulte-Merker; Benjamin M. Hogan The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3899–3910.
Published: 15 November 2010
...Emma J. Gordon; Sujata Rao; Jeffrey W. Pollard; Stephen L. Nutt; Richard A. Lang; Natasha L. Harvey Macrophages have been suggested to stimulate neo-lymphangiogenesis in settings of inflammation via two potential mechanisms: (1) acting as a source of lymphatic endothelial progenitor cells via the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 1003–1013.
Published: 15 March 2010
... normal development, and also provide a novel aspect of VEGFR3 signalling modulated by Ras in lymphangiogenesis. * Author for correspondence ( h-ichise@ims.u-tokyo.ac.jp ) Competing interests statement The authors declare no competing financial interests. 19 1 2010 © 2010. 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 4043–4053.
Published: 01 December 2009
... embryo survival is increased, such that the role of Rac1 in both sprouting angiogenesis and lymphangiogenesis could be investigated. We demonstrate that when endothelial Rac1 is deleted, blood vessels appear normal, but we reveal a previously unknown role for this Rho GTPase in regulating lymphatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (14): 2385–2391.
Published: 15 July 2009
... ) * These authors contributed equally to this work 12 5 2009 © 2009. 2009 Genetic modifier Sox genes Prox1 Lymphangiogenesis HLT syndrome Mouse The expression of different phenotypes caused by the same mutation is commonly attributed to genetic modifiers( Nadeau, 2001...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 191–195.
Published: 15 January 2009
... © 2009. 2009 Mouse PLCγ2 Lymphangiogenesis Vascular separation Bone marrow-derived cells Endothelial cell The lymphatic vasculature originates from the blood vasculature during development. Previous studies have demonstrated that the differentiation of lymphatic endothelial cells (LECs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1903–1911.
Published: 01 June 2008
... angiogenesis and lymphangiogenesis. Accordingly, the specific knockdown of Xc-Myc provokes massive embryonic edema and hemorrhage. Conversely, Xc-Myc overexpression triggers the formation of ectopic vascular beds in embryos. Myc is required for normal expression of Slug/Snail2 and Twist , and either XSlug...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (20): 4797–4806.
Published: 15 October 2002
...., Veikkola, T., Karpanen, T., Kettunen, T., Pulkkanen, K. J., Kauppinen, R., Jackson, D. G., Kubo, H., Nishikawa, S. I. et al. ( 2001 ). Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat. Med . 7 , 199 -205. Mandriota, S. J...