...Weiquan Lu; Stella E. Tsirka Lurcher is a spontaneous mouse mutant characterized by premature and aberrant apoptosis in the cerebellum. The phenotype has been shown to be caused by a point mutation in the δ2 glutamate receptor subunit gene that results in a large constitutive inward current, which...

... populations have a demonstrated developmental dependency on their synaptic target, the cerebellar Purkinje cell. Two mouse neurological mutants, staggerer ( sg/sg ) and lurcher (+/ Lc ), are characterized by intrinsic Purkinje cell deficiencies and, in both mutants, substantial numbers of cerebellar granule...

...Deborah J. Norman; Lei Feng; Susie S. Cheng; John Gubbay; Emily Chan; Nathaniel Heintz ABSTRACT In the neurologically mutant mouse strain lurcher ( Lc ), heterozygous animals display cell autonomous degeneration of cerebellar Purkinje cells beginning in the second postnatal week. During the course...