... a tetraploid-based organ complementation method, and the resulting rat lung epithelial cells exhibited species-specific development. Tetraploid-based organ complementation Interspecies chimera Lung development Fgfr2b Species-specific development Japan Society for the Promotion of Science...

... TGFβ in epithelial cells. To understand the role of mesenchymal G αq/11 in lung development, we generated constitutive ( Pdgfrb-Cre +/− ;Gnaq fl/fl ;Gna11 −/− ) and inducible ( Pdgfrb-Cre/ERT2 +/− ;Gnaq fl/fl ;Gna11 −/− ) mesenchymal G αq/11 deleted mice. Mice with constitutive G αq/11 gene deletion...

... into three axes (vascular, epithelial and interstitial) and show two populations of myofibroblasts. Lung development Mesenchymal cells Single-cell genomics 3D imaging Mouse University of Texas MD Anderson Cancer Center http://dx.doi.org/10.13039/100007313 National Institutes...

... by The Company of Biologists Ltd 2021 Summary: Time-series single-cell transcriptomic analysis identifies previously unrecognized transitional states, population dynamics, fate trajectories and gene-expression evolution in the developing mouse lung. Lung development Single-cell transcriptomics...

...). To evaluate whether the pneumosphere culture was a reliable method to study regulators of Sox9 + progenitor cells, we assessed the effect of known regulators of lung developmental pathways on proliferation and survival. Fibroblast growth factor 10 (Fgf10) is essential during lung development, particularly...

... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: During postnatal lung development, two major mesenchymal cell types have different developmental fates: most alveolar myofibroblasts are cleared from the lung by phagocytic cells, while alveolar lipofibroblasts are retained...

... by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: The MDM2-p53 axis determines lung progenitor cell number and subsequent organ size, but not airway patterning and cell differentiation. Lung development Respiratory progenitors Organ size E3 ubiquitin...

... Alveolar formation Elastogenesis Lung development Secondary crest myofibroblast Mouse Human National Institutes of Health 10.13039/100000002 HL122764 HL143059 HL144932 HL135747 Hastings Foundation The mammalian lung is an efficient gas exchange organ...

...Benjamin J. van Soldt; Jun Qian; Jiao Li; Nan Tang; Jining Lu; Wellington V. Cardoso ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar...

...-mesenchymal interactions in pulmonary fibrosis . Annu. Rev. Physiol.   73 , 413 - 435 . 10.1146/annurev-physiol-012110-142225 Desai , T. J. , Brownfield , D. G. and Krasnow , M. A. ( 2014 ). Alveolar progenitor and stem cells in lung development, renewal and cancer . Nature   507...

.../user-licence-1-1/ Summary: CTNNB1-mediated Wnt signaling maintains lung fate and suppresses gastrointestinal fate of mouse and human SOX9 progenitors, maintaining NKX2.1 and inhibiting SOX2 in a developmental stage-specific manner. Lung development Epithelial progenitors Beta-catenin...

...Rongbo Li; John C. Herriges; Lin Chen; Robert P. Mecham; Xin Sun Alveologenesis, the final step of lung development, is characterized by the formation of millions of alveolar septa that constitute the vast gas-exchange surface area. The genetic network driving alveologenesis is poorly understood...

... by The Company of Biologists Ltd 2016 Summary: The PRC component Ezh2 acts cell-autonomously in the developing mouse lung mesothelium to repress smooth muscle differentiation and allow appropriate cell fate decisions to occur. Ezh2 Polycomb repressive complex 2 Lung development Smooth muscle...

...Usua Laresgoiti; Marko Z. Nikolić; Chandrika Rao; Jane L. Brady; Rachel V. Richardson; Emma J. Batchen; Karen E. Chapman; Emma L. Rawlins Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first...

.... and Krasnow , M. A. ( 2014 ). Alveolar progenitor and stem cells in lung development, renewal and cancer . Nature   507 , 190 - 194 . 10.1038/nature12930 Epelman , S. , Lavine , K. J. , Beaudin , A. E. , Sojka , D. K. , Carrero , J. A. , Calderon , B. , Brija , T...

... . Desai , T. J. , Brownfield , D. G. and Krasnow , M. A. ( 2014 ). Alveolar progenitor and stem cells in lung development, renewal and cancer . Nature   507 , 190 - 194 . 10.1038/nature12930 Flodby , P. , Borok , Z. , Banfalvi , A. , Zhou , B. , Gao , D. , Minoo...

.... Polycomb repressive complex 2 Ezh2 Lung development Basal cells IGF1 Mouse In the mouse embryonic lung, an epithelial hierarchy has been proposed where multi-lineage progenitor cells give rise to the mature lung epithelial cells ( Alanis et al., 2014 ). Airway cells including club, ciliated...

... epithelial β-catenin signaling, which negatively regulates Sox2 expression. As such, these findings support a model in which the main function of Fgf10 during lung development is to regulate proximal-distal differentiation. As the lung buds grow out, proximal epithelial cells become further and further...

... no competing financial interests. 9 3 2011 © 2011. 2011 Branching morphogenesis Lung development Vascular network Mouse The past decade has brought about a conceptual shift regarding the role of the vasculature during organogenesis. Traditionally, blood vessels were thought...

... for correspondence( [email protected] ) * Present address: Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK 7 9 2009 © 2009. 2009 Progenitor cells Cre Lineage tracing Lung development Epithelium Mouse lung development involves four histological stages...