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Keywords: Lung development
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Journal Articles
Journal: Development
Development (2024) 151 (1): dev202081.
Published: 5 January 2024
... a tetraploid-based organ complementation method, and the resulting rat lung epithelial cells exhibited species-specific development. Tetraploid-based organ complementation Interspecies chimera Lung development Fgfr2b Species-specific development Japan Society for the Promotion of Science...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (9): dev201046.
Published: 12 May 2023
... TGFβ in epithelial cells. To understand the role of mesenchymal G αq/11 in lung development, we generated constitutive ( Pdgfrb-Cre +/− ;Gnaq fl/fl ;Gna11 −/− ) and inducible ( Pdgfrb-Cre/ERT2 +/− ;Gnaq fl/fl ;Gna11 −/− ) mesenchymal G αq/11 deleted mice. Mice with constitutive G αq/11 gene deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200081.
Published: 18 March 2022
... into three axes (vascular, epithelial and interstitial) and show two populations of myofibroblasts. Lung development Mesenchymal cells Single-cell genomics 3D imaging Mouse University of Texas MD Anderson Cancer Center http://dx.doi.org/10.13039/100007313 National Institutes...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: During postnatal lung development, two major mesenchymal cell types have different developmental fates: most alveolar myofibroblasts are cleared from the lung by phagocytic cells, while alveolar lipofibroblasts are retained...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev179820.
Published: 16 December 2019
... by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: The MDM2-p53 axis determines lung progenitor cell number and subsequent organ size, but not airway patterning and cell differentiation. Lung development Respiratory progenitors Organ size E3 ubiquitin...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (9): dev175810.
Published: 1 May 2019
...Benjamin J. van Soldt; Jun Qian; Jiao Li; Nan Tang; Jining Lu; Wellington V. Cardoso ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev161976.
Published: 10 April 2018
... interactions in pulmonary fibrosis . Annu. Rev. Physiol.   73 , 413 - 435 . 10.1146/annurev-physiol-012110-142225 Desai , T. J. , Brownfield , D. G. and Krasnow , M. A. ( 2014 ). Alveolar progenitor and stem cells in lung development, renewal and cancer . Nature   507 , 190 - 194...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev160788.
Published: 9 March 2018
... via temporal regulation of Wnt signaling . Cell Stem Cell   20 , 844 - 857.e6 . 10.1016/j.stem.2017.03.001 Metzger , R. J. , Klein , O. D. , Martin , G. R. and Krasnow , M. A. ( 2008 ). The branching programme of mouse lung development . Nature   453 , 745 - 750...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4563–4572.
Published: 15 December 2017
...Rongbo Li; John C. Herriges; Lin Chen; Robert P. Mecham; Xin Sun Alveologenesis, the final step of lung development, is characterized by the formation of millions of alveolar septa that constitute the vast gas-exchange surface area. The genetic network driving alveologenesis is poorly understood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3733–3741.
Published: 15 October 2016
... by The Company of Biologists Ltd 2016 Summary: The PRC component Ezh2 acts cell-autonomously in the developing mouse lung mesothelium to repress smooth muscle differentiation and allow appropriate cell fate decisions to occur. Ezh2 Polycomb repressive complex 2 Lung development Smooth muscle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3686–3699.
Published: 15 October 2016
...Usua Laresgoiti; Marko Z. Nikolić; Chandrika Rao; Jane L. Brady; Rachel V. Richardson; Emma J. Batchen; Karen E. Chapman; Emma L. Rawlins Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1318–1327.
Published: 15 April 2016
... the lung in three waves, each giving rise to a distinct lineage that expresses different markers, resides in a different location and renews in a different way. Lineage tracing Lung development Lung macrophage Parabiosis Phagocytosis Macrophages are professional phagocytes found in all...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 54–65.
Published: 1 January 2016
... 2015 11 11 2015 © 2016. Published by The Company of Biologists Ltd 2016 Highlighted article: Mouse lung alveolar type 1 cells form expansive thin cellular extensions via a non-proliferative two-step process, while retaining cellular plasticity. Lung development Cell plasticity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1458–1469.
Published: 15 April 2015
.... Polycomb repressive complex 2 Ezh2 Lung development Basal cells IGF1 Mouse In the mouse embryonic lung, an epithelial hierarchy has been proposed where multi-lineage progenitor cells give rise to the mature lung epithelial cells ( Alanis et al., 2014 ). Airway cells including club, ciliated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3731–3742.
Published: 15 September 2013
... epithelial β-catenin signaling, which negatively regulates Sox2 expression. As such, these findings support a model in which the main function of Fgf10 during lung development is to regulate proximal-distal differentiation. As the lung buds grow out, proximal epithelial cells become further and further...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2359–2368.
Published: 1 June 2011
... ). Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung . Development 124 , 4867 - 4878 . Cardoso W. V. , Lu J. ( 2006 ). Regulation of early lung morphogenesis: questions, facts and controversies . Development 133 , 1611 - 1624 . Clark J...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3741–3745.
Published: 15 November 2009
... embryonic lung development (for example, compare Fig. 4B with 4C ). This is analogous to kidney development, in which cell mixing in the branching tip has been observed ( Shakya et al.,2005 ). By contrast, patches of lineage-labeled cells were observed in all postnatal lungs examined ( Fig. 4D,E...
Includes: Supplementary data