... into three axes (vascular, epithelial and interstitial) and show two populations of myofibroblasts. Lung development Mesenchymal cells Single-cell genomics 3D imaging Mouse University of Texas MD Anderson Cancer Center http://dx.doi.org/10.13039/100007313 National Institutes...

... by The Company of Biologists Ltd 2021 Summary: Time-series single-cell transcriptomic analysis identifies previously unrecognized transitional states, population dynamics, fate trajectories and gene-expression evolution in the developing mouse lung. Lung development Single-cell transcriptomics...

... of lung developmental pathways on proliferation and survival. Fibroblast growth factor 10 (Fgf10) is essential during lung development, particularly in branching morphogenesis where Fgf10, expressed in the lung mesoderm, signals to its receptors, Fgfr1/2, in the endoderm to promote growth of Sox9...

... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: During postnatal lung development, two major mesenchymal cell types have different developmental fates: most alveolar myofibroblasts are cleared from the lung by phagocytic cells, while alveolar lipofibroblasts are retained...

... progenitor cell number and subsequent organ size, but not airway patterning and cell differentiation. Lung development Respiratory progenitors Organ size E3 ubiquitin ligase Trp53 The respiratory primordium initiates with the emergence of a small cluster of progenitors in the anterior...

... , A. ( 2008 ). Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?   Am. J. Physiol. Lung Cell. Mol. Physiol.   294 , L3 - L14 . 10.1152/ajplung.00362.2007 Boström , H...

...Benjamin J. van Soldt; Jun Qian; Jiao Li; Nan Tang; Jining Lu; Wellington V. Cardoso ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar...

...) together with alveolar simplification compared with control lungs ( Fig. 3 D,E). These results indicate that postnatal deletion of Pdgfa is sufficient to mimic the lung phenotype seen when Pdgfa is deleted during embryonic lung development, and that the effects of Pdgfa deletion are important during...

..., including epithelial-mesenchymal crosstalk, and to further explore its relevance in human lung development and regeneration ( Morrisey and Hogan, 2010 ; Ornitz and Yin, 2012 ; Herriges et al., 2015 ). * Author for correspondence ( jchen16@mdanderson.org ) Competing interests The authors...

...Rongbo Li; John C. Herriges; Lin Chen; Robert P. Mecham; Xin Sun Alveologenesis, the final step of lung development, is characterized by the formation of millions of alveolar septa that constitute the vast gas-exchange surface area. The genetic network driving alveologenesis is poorly understood...

.... ( 2015 ). Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung . Development   142 , 1458 - 1469 . 10.1242/dev.122077 Greulich , F. , Farin , H. F. , Schuster-Gossler , K. and Kispert , A. ( 2012 ). Tbx18 function in epicardial...

...Usua Laresgoiti; Marko Z. Nikolić; Chandrika Rao; Jane L. Brady; Rachel V. Richardson; Emma J. Batchen; Karen E. Chapman; Emma L. Rawlins Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first...

... ). Scale bars: 20 μm. (E) Quantification of abundance of F4/80 + and Mac2 + macrophages throughout embryonic lung development. F4/80 macrophages dominate early in lung development and Mac2 macrophages dominate after E15.5. Values shown are mean±s.e.m. for n =750-3570 macrophages scored in two or three...

.... and Krasnow , M. A. ( 2014 ). Alveolar progenitor and stem cells in lung development, renewal and cancer . Nature   507 , 190 - 194 . 10.1038/nature12930 Flodby , P. , Borok , Z. , Banfalvi , A. , Zhou , B. , Gao , D. , Minoo , P. , Ann , D. K. , Morrisey , E. E...

.... Polycomb repressive complex 2 Ezh2 Lung development Basal cells IGF1 Mouse In the mouse embryonic lung, an epithelial hierarchy has been proposed where multi-lineage progenitor cells give rise to the mature lung epithelial cells ( Alanis et al., 2014 ). Airway cells including club, ciliated...

... epithelial β-catenin signaling, which negatively regulates Sox2 expression. As such, these findings support a model in which the main function of Fgf10 during lung development is to regulate proximal-distal differentiation. As the lung buds grow out, proximal epithelial cells become further and further...

... vascular patterning in the embryonic lung . Dev. Biol. 264 , 443 - 455 . Bellusci S. , Grindley J. , Emoto H. , Itoh N. , Hogan B. L. ( 1997 ). Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung . Development 124 , 4867...

... for correspondence( b.hogan@cellbio.duke.edu ) * Present address: Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK 7 9 2009 © 2009. 2009 Progenitor cells Cre Lineage tracing Lung development Epithelium Mouse lung development involves four histological stages...

... and tumors in multiple organs. We have determined that the early lethality in Mig-6 -/- mice occurs in the perinatal period, with mice displaying abnormal lung development. Histological examination of Mig-6 -/- lungs (E15.5-P3) revealed reduced septation,airway over-branching, alveolar type II cell...

... © 2009. 2009 Notch Pofut1 Rbpjk (Rbpj) Cell fate Lung development Airway differentiation Ciliated cell Clara cell Neuroendocrine cell The respiratory system represents a major interface between the body and the external environment, serving functions as diverse as mucociliary...