... epithelial architecture and lumen formation both in vivo and in three-dimensional (3D) primary cell cultures. Collectively, these results demonstrate that Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis. Mammary epithelial...

... in the transverse plane, allowing sufficient time for lumen growth via an osmotic process along the longitudinal dimension. The dynamics of lumen formation is controlled by the TGFβ pathway and ROCK activity. Our findings reveal a TGFβ-ROCK-actomyosin contractility axis that coordinates lumen growth, which...

...John C. Pelton; Catherine E. Wright; Michael Leitges; Victoria L. Bautch Blood vessel polarization in the apical-basal axis is important for directed secretion of proteins and lumen formation; yet, when and how polarization occurs in the context of angiogenic sprouting is not well understood. Here...

... findings not only identify a novel mechanism of vascular lumen formation, but also suggest a new form of developmental crosstalk between hematopoietic and endothelial cell lineages. References Ando R. , Hama H. , Yamamoto-Hino M. , Mizuno H. , Miyawaki A. ( 2002...

... interests statement The authors declare no competing financial interests. 2 8 2011 © 2011. Cell polarity Shroom3 Apical constriction Cell elongation Interkinetic nuclear migration Lumen formation Mouse When formed at embryonic day (E) 9.5, the murine...

... a mesenchymal-epithelial transition and form two apical domains at opposite ends. Extracellular lumens then form at the apical surfaces. We show that cortical actin and Ciona ezrin/radixin/moesin (ERM) are essential for lumen formation and that a polarized network of microtubules, which contributes to lumen...