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Keywords: Lrp6
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Journal Articles
Journal: Development
Development (2016) 143 (24): 4723–4735.
Published: 15 December 2016
... in Eda-ablated Tabby mice. Consistent with transient Dkk4 action, intact Dkk4 inhibits MG extension but the cleaved form progressively increases during MG development with a concomitant upswing in Wnt activity. Furthermore, both Dkk4 and its receptor (and Wnt co-receptor) Lrp6 are direct Eda targets...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4509–4520.
Published: 01 December 2016
... that the actin-binding protein filamin A (FlnA) physically interacts with the actin-nucleating protein formin 2 (Fmn2). Loss of FlnA and Fmn2 impairs proliferation, thereby generating multiple embryonic phenotypes, including microcephaly. FlnA interacts with the Wnt co-receptor Lrp6. Loss of FlnA and Fmn2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 667–676.
Published: 15 February 2011
... in the precursors of the craniofacial structures and leads to a complete truncation of the head at early organogenesis. Here, we show that ENU-induced mutations of genes coding for two WNT canonical pathway factors, the co-receptor LRP6 and the transcriptional co-activator β-catenin, also elicit an ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (18): 3161–3171.
Published: 15 September 2009
... inactivation of Lrp6, a co-receptor of the Wnt/β-catenin signaling pathway, leads to cleft lip with cleft palate. The activity of a Wnt signaling reporter is blocked in the orofacial primordia by Lrp6 deletion in mice. The morphological dynamic that is required for normal lip formation and fusion is disrupted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1049–1058.
Published: 15 March 2008
...Sheila M. Bell; Claire M. Schreiner; Susan E. Wert; Michael L. Mucenski; William J. Scott; Jeffrey A. Whitsett Herein, we demonstrate that Lrp6-mediated R-spondin 2 signaling through the canonical Wnt pathway is required for normal morphogenesis of the respiratory tract and limbs. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
... of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4255–4263.
Published: 01 December 2007
... independently from Dkks during neural crest (NC) induction in Xenopus. Krm2 is co-expressed with, and regulated by, canonical Wnts. Krm2 is differentially expressed in the NC, and morpholino-mediated Krm2 knockdown inhibits NC induction, which is mimicked by LRP6 depletion. Conversely, krm2 overexpression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (22): 4095–4106.
Published: 15 November 2007
...Emilios Tahinci; Curtis A. Thorne; Jeffrey L. Franklin; Adrian Salic; Kelly M. Christian; Laura A. Lee; Robert J. Coffey; Ethan Lee Wnt signaling regulates β-catenin-mediated gene transcription and planar cell polarity (PCP). The Wnt co-receptor, Lrp6, is required for signaling along the β-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 503–513.
Published: 01 February 2007
...Matt Kofron; Bilge Birsoy; Douglas Houston; Qinghua Tao; Christopher Wylie; Janet Heasman Current models of canonical Wnt signaling assume that a pathway is active if β-catenin becomes nuclearly localized and Wnt target genes are transcribed. We show that, in Xenopus , maternal LRP6 is essential...
Journal Articles
Journal: Development
Development (2004) 131 (21): 5469–5480.
Published: 01 November 2004
...Chikara Kokubu; Ulrich Heinzmann; Tomoko Kokubu; Norio Sakai; Takuo Kubota; Masanobu Kawai; Matthias B. Wahl; Juan Galceran; Rudolf Grosschedl; Keiichi Ozono; Kenji Imai Here, we present evidence that Lrp6, a coreceptor for Wnt ligands, is required for the normal formation of somites and bones...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2803–2815.
Published: 15 June 2004
...Olivia G. Kelly; Kathy I. Pinson; William C. Skarnes Recent work has identified LDL receptor-related family members, Lrp5 and Lrp6, as co-receptors for the transduction of Wnt signals. Our analysis of mice carrying mutations in both Lrp5 and Lrp6 demonstrates that the functions of these genes...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2543–2552.
Published: 01 June 2004
... demonstrated interaction between Dkk1 and the Wnt coreceptors Lrp5 and Lrp6 by analysis of several types of double mutants. The polydactyly of Dkk1 d/d mice was corrected by reduced expression of Lrp5 or Lrp6 . The posterior digit loss and axial truncation characteristic of Lrp6 null mice was partially...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2137–2147.
Published: 01 May 2004
... demonstrate, using Xenopus embryos, that CTGF also regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6). This interaction is likely to occur through the C-terminal (CT) domain of CTGF,which is distinct from the BMP...