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Journal Articles

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

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Xing Ma, Yingying Han, Xiaoqing Song, Trieu Do, Zhihao Yang, Jianquan Ni, Ting Xie
Journal: Development
Development (2016) 143 (23): 4312–4323.
https://doi.org/10.1242/dev.141069
Published: 1 December 2016
... and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both heatshock-inducible endonuclease I-CreI expression and X-ray irradiation can efficiently introduce double-strand breaks...
View article titled, DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
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Includes: Supplementary data