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Keywords: Lmx1b
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Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 01 June 2017
...Endika Haro; Billy A. Watson; Jennifer M. Feenstra; Luke Tegeler; Charmaine U. Pira; Subburaman Mohan; Kerby C. Oberg Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1181–1188.
Published: 01 April 2010
... the coordination of musculoskeletal patterning during mouse limb development. Using both conditional gain- and loss-of-function approaches, we selectively deleted or activated the LIM-homeodomain transcription factor Lmx1b in skeletal progenitors using a Sox9-Cre knock-in allele. As Lmx1b is both necessary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1375–1385.
Published: 15 April 2009
..., it is unknown how these signaling interactions are processed in the responding cells. We have found that distinct LIM homeodomain transcription factors, encoded by the LIM homeobox(LIM-HD) genes Lhx2, Lhx9 and Lmx1b integrate the signaling events that link limb patterning and outgrowth along all three axes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3713–3722.
Published: 15 October 2007
... that the territory corresponding to the limb dorsal compartment correlates with the expression domain of the transcription factor Lmx1b. Eliminating Lmx1b function in the mouse results in double-ventral limbs ( Chen et al., 1998 ), and overexpression of the ortholog gene Lmx1 in chicken results in double-dorsal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (2): 317–325.
Published: 15 January 2007
...). However, transcriptional regulation of these secreted factors during development remains to be elucidated. Here we show that the LIM homeobox gene Lmx1b is expressed in the anterior embryo as early as E7.5 and its expression becomes progressively restricted to the isthmus at E9.0. Analysis of gene...
Journal Articles
Journal: Development
Development (2006) 133 (7): 1219–1229.
Published: 01 April 2006
..., in these limbs, the expression of Bmp2, Bmp4 and Bmp7 , and of the Bmp target genes Msx1,Msx2 and gremlin, is expanded in the mesenchyme. Furthermore, we found that the expression of Lmx1b , a gene exclusively expressed in the dorsal limb mesenchyme and involved in dorsoventral patterning, is reduced upon loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3163–3173.
Published: 15 July 2005
... that the LIM homeobox transcription factor Lmx1b is expressed within the chick IsO, where it is sufficient to maintain expression of the secreted factor wnt1 . In this paper, we show that zebrafish express two Lmx1b orthologs, lmx1b.1 and lmx1b.2 , in the rostral IsO, and demonstrate that these genes...
Journal Articles
Journal: Development
Development (2004) 131 (15): 3693–3703.
Published: 01 August 2004
... report that the differentiation and migration of the superficial dorsal horn neurons are regulated by the LIM homeobox gene Lmx1b , and its downstream targets Rnx and Drg11 , two transcription factors implicated in the development of dorsal horn circuitry. An analysis of Lmx1b mutants shows that Lmx1b...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (22): 5269–5277.
Published: 15 November 2002
.... Involvement of Wnt1 in the isthmic organizing activity was suggested by analysis of Wnt1 knockout mice. But its role in isthmic organizing activity is still obscure. Recently, it has been shown that Lmx1b is expressed in the isthmic region and that it may occupy higher hierarchical position in the gene...