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Keywords: Lmx1b
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Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 1 June 2017
...Endika Haro; Billy A. Watson; Jennifer M. Feenstra; Luke Tegeler; Charmaine U. Pira; Subburaman Mohan; Kerby C. Oberg Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (8): 1375–1385.
Published: 15 April 2009
..., it is unknown how these signaling interactions are processed in the responding cells. We have found that distinct LIM homeodomain transcription factors, encoded by the LIM homeobox(LIM-HD) genes Lhx2, Lhx9 and Lmx1b integrate the signaling events that link limb patterning and outgrowth along all three axes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3713–3722.
Published: 15 October 2007
... of cell dispersion at specific axial positions. * Author for correspondence (e-mail: mtorres@cnic.es ) 25 5 2007 © 2007. 2007 Clonal analysis Fate maps Vertebrate limb Lineage compartments Lmx1b Patterning of embryonic primordia involves tight regulation of cell...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (7): 1219–1229.
Published: 1 April 2006
..., in these limbs, the expression of Bmp2, Bmp4 and Bmp7 , and of the Bmp target genes Msx1,Msx2 and gremlin, is expanded in the mesenchyme. Furthermore, we found that the expression of Lmx1b , a gene exclusively expressed in the dorsal limb mesenchyme and involved in dorsoventral patterning, is reduced upon loss...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (15): 3693–3703.
Published: 1 August 2004
... report that the differentiation and migration of the superficial dorsal horn neurons are regulated by the LIM homeobox gene Lmx1b , and its downstream targets Rnx and Drg11 , two transcription factors implicated in the development of dorsal horn circuitry. An analysis of Lmx1b mutants shows that Lmx1b...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (22): 5269–5277.
Published: 15 November 2002
.... Involvement of Wnt1 in the isthmic organizing activity was suggested by analysis of Wnt1 knockout mice. But its role in isthmic organizing activity is still obscure. Recently, it has been shown that Lmx1b is expressed in the isthmic region and that it may occupy higher hierarchical position in the gene...
Journal Articles
Journal: Development
Development (2001) 128 (2): 181–191.
Published: 15 January 2001
... . Lmx1b was recently implicated as a positive regulator of Wnt1 mes/met expression in chick ( Adams et al., 2000 ). Consistent with this, we found that Lmx1b was induced by FGF8 several hours before Wnt1 , and scattered expression of both genes was seen initially. By 40 hours, however, Wnt1...
Journal Articles
Journal: Development
Development (2000) 127 (9): 1857–1867.
Published: 1 May 2000
... which eventually defines the mesencephalic/ metencephalic boundary (MMB). Here we report that the transcription factor Lmx1b is expressed and functions in a distinct region of the IsO. Lmx1b expression is maintained by the glycoprotein Fgf8 , a signal capable of mediating IsO signaling. Lmx1b, in turn...
Journal Articles
Journal: Development
Development (1998) 125 (6): 1137–1148.
Published: 15 March 1998
... of the broadened mutant AER and the distal border of an ectopic Lmx1b expression domain. Analysis of En1/Wnt7a double mutants demonstrates that the dorsalizing gene Wnt7a is required for the formation of the ectopic AERs in En1 mutants and for ectopic expression of Lmx1b in the ventral mesenchyme. We suggest...