... transcription factor (TF)-binding sites for cortical hem-patterning TFs. We found that the homeobox TF Lmx1a can activate the Cux2 enhancer in vitro . Furthermore, we showed that Lmx1a-binding sites were required for enhancer activity in the cortical hem in vivo . Mis-expression of Lmx1a in hippocampal...

... larval stages with the formation of terminal filament-cap structures; however, the genetics underlying their development remains largely unknown. Here, we show that the transcription factor Lmx1a is required for ovary morphogenesis. We found that Lmx1a is expressed in early ovarian somatic lineages...

... for cholecystokinin and secretin production. In all stages and Nkx2.2 mutant conditions, serotonin-producing enterochromaffin cells were the most severely reduced enteroendocrine lineage in the duodenum and colon. We determined that the transcription factor Lmx1a is expressed in enterochromaffin cells and functions...

... pathway that controls the differentiation of mesDA neurons shows that, in the absence of Otx2, the expression of Lmx1a and Msx1 , and the proneural genes Ngn2 and Mash1 is not activated in Sox2 + mesDA progenitors, which largely fail to differentiate into Nurr1 + mesDA precursors. Furthermore...

... neurogenic activity and generate mesDA neurons in vitro. By contrast, sorted caudal FP cells have no neurogenic potential, as previously thought. Analysis of dreher mutant mice carrying a mutation in the Lmx1a locus and transgenic mice ectopically expressing Otx2 in caudal FP cells demonstrated that Otx2...

.... 11 , 43 -49. Chizhikov, V. and Millen, K. J. ( 2003 ). Development and malformations of the cerebellum in mice. Mol. Genet. Metab. 80 , 54 -65. Chizhikov, V. V. and Millen, K. J. ( 2004a ). Control of roof plate formation by Lmx1a in the developing spinal cord. Development 131 , 2693...

... and dI1 sensory interneurons. We demonstrate that the LIM homeodomain transcription factor, Lmx1a ,mutated in the dreher mouse, acts to withdraw dorsal spinal cord progenitors from the cell cycle and simultaneously direct their differentiation into functional roof plate cells. Lmx1a cell-autonomously...