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Keywords: Lkb1
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Journal Articles
Journal: Development
Development (2010) 137 (4): 661–670.
Published: 15 February 2010
...Patrick Narbonne; Vincent Hyenne; Shaolin Li; Jean-Claude Labbé; Richard Roy The protein kinase LKB1 is a crucial regulator of cell growth/proliferation and cell polarity and is the causative gene in the cancer-predisposing disease Peutz-Jeghers syndrome (PJS). The activity of LKB1 is greatly...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 93–102.
Published: 1 January 2010
... suppressor kinase, LKB1, in the presence of a pseudokinase, STRADα, initiates axonal differentiation and growth through activating the SAD kinases in vertebrate neurons. STRADα was implicated in the localization, stabilization and activation of LKB1 in various cell culture studies. Its in vivo functions...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
...Patrick Narbonne; Richard Roy In C. elegans , reduced insulin-like signalling induces developmental quiescence, reproductive delay and lifespan extension. We show here that the C. elegans orthologues of LKB1 and AMPK cooperate during conditions of reduced insulin-like signalling to establish cell...