...Maarten P. Bebelman; Lenka Belicova; Elzbieta Gralinska; Tobias Jumel; Aparajita Lahree; Sarah Sommer; Andrej Shevchenko; Timofei Zatsepin; Yannis Kalaidzidis; Martin Vingron; Marino Zerial ABSTRACT During liver development, bipotential progenitor cells called hepatoblasts differentiate...

... ALK1/ACVRL1 BMP Endothelial cells Liver sinusoid PI3K Adherens junctions Contractility Liver development Vascular barrier National Institutes of Health R35 HL139950 National Heart, Lung, and Blood Institute http://dx.doi.org/10.13039/100000050 R35 HL139950...

...Lila Gannoun; Catalina De Schrevel; Morgane Belle; Nicolas Dauguet; Younes Achouri; Axelle Loriot; Christophe Vanderaa; Sabine Cordi; Alexandra Dili; Yves Heremans; Ilse Rooman; Isabelle A. Leclercq; Patrick Jacquemin; Laurent Gatto; Frédéric P. Lemaigre ABSTRACT Earlier data on liver development...

... surface-exposed components . Cancer Res.   48 , 4909 - 4918 . Gordillo , M. , Evans , T. and Gouon-Evans , V. ( 2015 ). Orchestrating liver development . Development   142 , 2094 - 2108 . 10.1242/dev.114215 Haghverdi , L. , Buettner , F. and Theis , F. J...

...Toru Suzuki; Chisato Kikuguchi; Saori Nishijima; Takeshi Nagashima; Akinori Takahashi; Mariko Okada; Tadashi Yamamoto ABSTRACT Liver development involves dramatic gene expression changes mediated by transcriptional and post-transcriptional control. Here, we show that the Cnot deadenylase complex...

.... Herein, we report a crucial role of CDK5RAP3 in liver development and hepatic functions. Cdk5rap3 knockout mice displayed prenatal lethality with severe liver hypoplasia, as characterized by delayed proliferation and compromised differentiation. Hepatocyte-specific Cdk5rap3 knockout mice suffered post...

... during early development of the liver. Much effort has been made to elucidate the molecular mechanisms that underlie liver development. Success in identifying proteins that control hepatic specification and hepatocyte differentiation has facilitated the generation of protocols that can be used...

... A, enrichment analysis revealed that the proteins that are abundantly expressed in both HE-iPSC/MSC and HE-iPSC/HUVEC cultures are typically expressed at the late stage of liver development. Paracrine factors that potentially play roles in hepatic differentiation were identified, including angiotensinogen (ANG...

... development and embryonic energy consumption remain unknown. Here, we demonstrate that genetic or chemical inhibition of cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish ( Danio rerio ), impacting hepatic differentiation, but not endodermal specification: loss...

... these cells interact, and how transcriptional and signaling programs precisely coordinate liver development, has begun to elucidate the molecular mechanisms underlying this complexity. Here, we review the lineage relationships, signaling pathways and transcriptional programs that orchestrate hepatogenesis...

... to proliferate and ultimately die - leading to reduced organ size. DNA methylation DNA replication Hepatic outgrowth Liver development UHRF1 Zebrafish Epigenetics is a fundamental mechanism underlying gene regulation and chromatin structure. Despite the crucial role epigenetics plays...

.... Endodermal nav3a expression was controlled by Wnt2bb signaling and was independent of FGF and BMP signaling. Morpholino-mediated knockdown of nav3a resulted in a significantly reduced liver size, and impaired development of pancreas and swim bladder. In vivo time-lapse imaging of liver development in nav3a...

... interests. 6 1 2011 © 2011. 2011 Wnt signaling Liver development Developmental competence Hepatic induction Endoderm Zebrafish The liver develops from the foregut endoderm in response to hepatic inducing signals such as Fgf ( Jung et al., 1999 ; Zhang et al., 2004...

... they are unable to form biliary tubes, revealing an instructive role of the vasculature in liver development. These findings uncover the cellular basis for the defining feature of AGS, identify mesenchymal Jag1-dependent and -independent stages of duct development, and provide mechanistic information for the role...

... galactose-specific receptors rat liver cells liver development hepatocyte macrophage The removal of plasma glycoproteins from the circulation and their catabolism are major hepatic roles; the binding occurs by means of specific carbohydrate-recognition systems located on hepatocyte surface...