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Keywords: Lipid droplets
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Journal Articles

Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets

Open Access
Michelle S. Giedt, Jonathon M. Thomalla, Roger P. White, Matthew R. Johnson, Zon Weng Lai, Tina L. Tootle, Michael A. Welte
Journal: Development
Development (2023) 150 (20): dev201516.
https://doi.org/10.1242/dev.201516
Published: 8 June 2023
...Michelle S. Giedt; Jonathon M. Thomalla; Roger P. White; Matthew R. Johnson; Zon Weng Lai; Tina L. Tootle; Michael A. Welte ABSTRACT Lipid droplets (LDs), crucial regulators of lipid metabolism, accumulate during oocyte development. However, their roles in fertility remain largely unknown. During...
View articletitled, Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets
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Includes: Supplementary data
Journal Articles

Drosophila embryos spatially sort their nutrient stores to facilitate their utilization

Free
Marcus D. Kilwein, Matthew R. Johnson, Jonathon M. Thomalla, Anthony P. Mahowald, Michael A. Welte
Journal: Development
Development (2023) 150 (20): dev201423.
https://doi.org/10.1242/dev.201423
Published: 17 March 2023
... and glycogen) are sequestered in distinct storage structures: lipid droplets (LDs), yolk vesicles (YVs) and glycogen granules (GGs). Using transmission electron microscopy as well as live and fixed sample fluorescence imaging, we find that all three storage structures are dispersed throughout the egg...
View articletitled, Drosophila embryos spatially sort their nutrient stores to facilitate their utilization
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Includes: Supplementary data
Journal Articles

Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones

Free
Roxan A. Stephenson, Jonathon M. Thomalla, Lili Chen, Petra Kolkhof, Roger P. White, Mathias Beller, Michael A. Welte
Journal: Development
Development (2021) 148 (15): dev199381.
https://doi.org/10.1242/dev.199381
Published: 6 August 2021
... H2B, H2A and H2Av accumulate on lipid droplets (LDs), which are cytoplasmic fat storage organelles. Without LD binding, maternally provided H2B, H2A and H2Av are absent; however, how LDs ensure histone storage is unclear. Using quantitative imaging, we uncover when during oogenesis these histones...
View articletitled, Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones
Open the PDF for Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones in another window
Includes: Supplementary data