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Keywords: Lineage tracing
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Journal Articles
Journal: Development
Development (2021) 148 (18): dev198994.
Published: 09 September 2021
... and applications to lineage tracing in live-imaging data and outline software methodologies that can be applied to various cell-tracking challenges. * These authors contributed equally to this work ‡ Author for correspondence ( kmcdole@mrc-lmb.cam.ac.uk ) Competing interests The authors...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev187534.
Published: 10 March 2021
... systems showing replacement of mechanosensory cells can provide mechanistic insights into developing new regenerative therapies. Here, we developed lineage tracing systems to reveal the generation of mechanosensory neurons in the Johnston's organ (JO) of intact adult Drosophila , which are the functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev197590.
Published: 16 December 2020
... surface epithelium. Ocular surface epithelium Limbal stem cells Label-retaining cell Lineage tracing Conjunctiva Stem cell compartment Mouse Tissue stem cells (SCs) play an important role in homeostasis and injury repair. Adult epithelial tissues – such as the skin, eye, oral mucosa...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
... and migration routes. By marking progenitor cells, one can observe their subsequent locations and the cell types into which they differentiate. Here, we review major discoveries in neural crest lineage tracing from a historical perspective. We discuss how advancing technologies have refined lineage-tracing...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192807.
Published: 09 October 2020
..., that are maintained in a lineage-restricted manner during homeostasis or after mild injuries. Glandular regeneration following a near complete loss of secretory cells, however, may involve cellular plasticity, although the mechanism and extent of such plasticity remain unclear. Here, by combining lineage-tracing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev180950.
Published: 13 July 2020
.../progenitor cells. However, the precise stem cell niche organization, the intermediate steps and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive. Quantitative lineage-tracing in vivo revealed that conditional deletion of fibroblast growth factor 10 (Fgf10) from Fgf10-expressing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev184481.
Published: 12 May 2020
... by equal base composition, 5′ G sequence, minimal likelihood of residing in the functional genome, minimal off targets and ease of amplification. We validate multiple high-quality endogenous CRISPR/Cas9 arrays , demonstrating their utility for lineage tracing. Our pragmatically scalable technique thus can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev184085.
Published: 11 March 2020
... into the neuropil ( Fig. 5 C). These results suggest that Pros is involved in the differentiation of adult ALG. To investigate the role of Pros in the lineages, we developed a gene knockdown (KD) system by modifying the flip-out lineage-tracing system, in which manipulated cells were labeled with cytoplasmic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
... allele to lineage trace AMFs, we demonstrate that most AMFs are developmentally cleared during alveologenesis. Lung mesenchyme also contains other poorly described cell types, including alveolar lipofibroblasts (ALF). We show that Gli1:CreERT2 marks both AMFs as well as ALFs, and lineage tracing shows...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180224.
Published: 23 October 2019
... are self-sustained in adult mice by unipotent lineage-restricted SCs. The spatiotemporal regulation of SC fate and the switch from multipotency to unipotency remain poorly characterised. Here, by combining lineage tracing, whole-tissue imaging, clonal analysis and proliferation kinetics, we uncover...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176180.
Published: 22 July 2019
... lineage tracing of cells with an expression history of IL7Rα, a marker exclusively associated with the lymphoid lineage in adult hematopoiesis. Surprisingly, we found that Il7r-Cre labeled fetal-derived, adult trMacs. Labeling was almost complete in some tissues and partial in others. The putative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev169730.
Published: 27 June 2019
... questions that can be addressed using single cell dynamic lineage tracing. Lineage tracing Lineage trees Single cell * Authors for correspondence ( aaron.mckenna@dartmouth.edu ; james.gagnon@utah.edu ) Funding A.M. was supported by the National Human Genome Research Institute...
Journal Articles
Journal: Development
Development (2018) 145 (19): dev168658.
Published: 11 October 2018
... organs. Furthermore as single-cell RNA-sequencing becomes more prevalent, its use as a predictive tool to infer developmental relationships will be strengthened and validated by single-cell lineage-tracing methods such as those presented herein. Homozygous Foxa2 mcm/mcm males (C57BL/6J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev166801.
Published: 17 August 2018
... ) Competing interests The authors declare no competing or financial interests. 20 4 2018 30 6 2018 © 2018. Published by The Company of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Embryonic cell lineage tracing of adipose tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164079.
Published: 25 July 2018
... under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Neutral, low-density lineage tracing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
.... As development proceeds, these clusters expand and further contribute to the growing lymphatic system. Lineage tracing and analyses of Gata2 -deficient mice confirmed that these clusters are endothelial in origin. Furthermore, ectopic expression of Vegfc in the vasculature increased the number of PROX1-positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev162305.
Published: 16 April 2018
... human placenta that appears to be regulated by NOTCH signalling and exhibits a unique combination of epithelial and mesenchymal expression characteristics. Placenta Stem cells Integrin α2 Progenitor Lineage tracing Despite the rapid growth of the human placenta in the early weeks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev147793.
Published: 09 January 2018
... Maternal-to-zygotic transition MZT Yolk syncytial layer YSL Zygotic genome activation ZGA Lineage tracing GESTALT Highlighted Article: Detailed analyses of zebrafish nanog mutants, including tissue-specific rescue and chimera analysis, indicate that Nanog is necessary for yolk syncytial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 755–766.
Published: 01 March 2017
...Purushothama Rao Tata; Jayaraj Rajagopal In contrast to a prior emphasis on the finality of cell fate decisions in developmental systems, cellular plasticity is now emerging as a general theme in the biology of multiple adult organ systems. In the lung, lineage tracing has been used to identify...
Journal Articles
Journal: Development
Development (2017) 144 (4): 580–589.
Published: 15 February 2017
... cluster, suggesting that they had recently exited the cell cycle ( Fig. 1 I). These results demonstrated that p53 -mTmG genetic lineage-tracing system could detect and trace neonatal cycling cardiomyocytes. In addition, we characterized and quantified the GFP + non-cardiomyocyte cells by cell...
Includes: Supplementary data