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Keywords: Lineage specification
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Journal Articles
Journal: Development
Development (2023) 150 (18): dev201494.
Published: 25 September 2023
... stem cell population that drives stomach patterning and lineage specification during development and continued homeostatic maintenance and regeneration in adulthood. Gastric stem cells Lineage specification Epithelial homeostasis Agency for Science, Technology and Research http...
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200263.
Published: 20 September 2022
... encapsulation of human and non-human primate PSCs establishes a powerful technical foundation for disentangling the signals that control embryogenesis and for addressing comparative evolutionary questions about extraembryonic lineage specification. Encapsulated primed cmPSCs readily formed Am-spheroids, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev193789.
Published: 7 January 2021
.... Model of spatial and temporal separation of DE and AM lineage specification downstream of Eomes . (A) Induction of Eomes by NODAL/SMAD2/3 signals leads to the specification of AM and DE lineages. AM marked by Mesp1 expression is generated in the proximal PS and Foxa2 -positive cells give rise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev169862.
Published: 15 November 2020
... benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev172916.
Published: 3 April 2019
... this formative transition highlights dynamic changes in gene expression, which affect many cellular properties including metabolism and epithelial features. Notably, naïve pluripotency factors are exchanged for postimplantation factors, but competent cells remain devoid of lineage-specific transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164384.
Published: 22 October 2018
... and are often associated with developmental diseases in humans. In this Primer, we discuss the unique and redundant functions of GATA proteins in tissue morphogenesis, with an emphasis on their regulation of lineage specification and early organogenesis. * These authors contributed equally to this work...
Journal Articles
Journal: Development
Development (2018) 145 (12): dev159103.
Published: 18 June 2018
... a conditional deletion system to investigate embryonic patterning and lineage specification in response to loss of Oct4. We first observe ectopic expression of Nanog in Oct4-negative postimplantation epiblast cells. The expression domains of lineage markers are subsequently disrupted. Definitive endoderm...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2017) 144 (3): 365–373.
Published: 1 February 2017
... formative pluripotency, exists between the naïve and primed states, and is enabling for the execution of pluripotency. Embryonic stem cells Pluripotency Epiblast Lineage specification Developmental potential Medical Research Council 10.13039/501100000265 Biotechnology...
Journal Articles
Journal: Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
... financial interests. 8 3 2016 17 8 2016 © 2016. Published by The Company of Biologists Ltd 2016 Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2013) 140 (21): 4311–4322.
Published: 1 November 2013
... This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Lineage specification...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2010) 137 (23): 3953–3963.
Published: 1 December 2010
... be one cause for the arrest of Klf5 – / – embryos. Fig. 2. Klf5 is required for TE lineage specification. ( A ) Cultured E2.5 Klf5 –/– mouse embryos do not form an expanded blastocoel or hatch. Morulae from Klf5 +/– intercrosses were cultured and monitored for 72 hours. Klf5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3081–3091.
Published: 15 September 2008
... reporter under the control of Pdgfra regulatory elements with the analysis of lineage-specific markers, we investigated the events leading to PrE and EPI lineage segregation in the mouse, and correlated our findings using an embryo staging system based on total cell number. Before blastocyst formation...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4219–4231.
Published: 1 December 2007
... Institute for Molecular Biomedicine, Mammalian Development Laboratory, Münster, Germany 31 8 2007 © 2007. 2007 Embryonic patterning Lineage specification Mouse pre-implantation embryos Mammalian embryonic development is characterized by an initial pre-implantation phase...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (1996) 122 (2): 555–566.
Published: 1 February 1996
... for correspondence 07 11 1995 © 1996 by Company of Biologists 1996 RU49 cerebellum granule cells transcription factor lineage specification mouse brain zinc finger The role of cell-type-specific transcription factors in lineage specification during invertebrate development ( Jan...