... is determined by the cell number and cell dispersion of cerebellar granule cell precursor clones, which vary on different sides of the lineage boundary between lobules. Foliation Lineage restriction Lobules Morphogenesis Polarized growth Engrailed mutants Mouse In order to produce an organ...

... that the establishment of trophoblast and embryonic lineages proceeds by a mechanism that is distinct from the program that regulates this lineage restriction in established ES cells or the epiblast. Here, we have used a combination of bioinformatic and functional genomic approaches to address fundamental...

... precursors for different thalamic nuclei display temporally distinct Gbx2 expression patterns. Gbx2 -expressing cells and their descendents form sharp lineage-restriction boundaries delineating the thalamus from the pretectum,epithalamus and prethalamus, revealing multiple compartmental boundaries within...

... their position with the expression of a midbrain marker, we demonstrate that midbrain and hindbrain cells arise from two distinct cell populations. Single cell labeling and analysis of the distribution of their progeny shows that lineage restriction is probably established during late gastrulation stages. Our...

... ridge * Author for correspondence (e-mail: [email protected] ) 08 09 1998 © 1997 by Company of Biologists 1997 dorso-ventral patterning AER compartment lineage restriction chick embryo limb development A fundamental question in the development...