... to the execution of this first lineage decision. In the absence of CHD4, this frequency is increased in 16-cell embryos, and by the blastocyst stage cells fail to properly adopt a TE gene expression programme. We propose that CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency...

.... Dev. Biol. 100 , 143 – 169 . Zebrafish Heart development Lineage commitment Cardiac fate Heart formation is a dynamic process involving cardiomyocyte progenitor (CP) specification, cell migration, cardiomyocyte differentiation and complex tissue morphogenesis ( Brand...

.... © 2012. 2012 Transcription factors Gene regulation Lineage commitment Throughout evolution, increases in organismal complexity have been associated with the development of intricate transcriptional regulatory mechanisms that control the differentiation of diverse tissues...

... Canonical Wnt signaling Lineage commitment Terminal osteoblast differentiation The mammalian skeleton forms from three distinct cell lineages( Nakashima and de Crombrugghe,2003 ). Facial bones and the cranium are derived from the neural crest. The base of the skull, the parietal bones...

... pluripotency is derived from an ancestral function of this class of proteins to maintain multipotency. * Author for correspondence (e-mail: [email protected] ) 3 3 2006 © 2006. 2006 Gastrulation Self-renewal Embryonic stem cell Lineage commitment Pou protein Pou5f1...