..., but its underlying mechanism remains poorly understood. Lin28 is an RNA-binding protein with two paralogs, Lin28a and Lin28b, in mammals. Mice with Lin28b deletion exhibit no developmental defects, whereas we have previously reported that Lin28a deletion leads to microcephaly. Here, we find that Lin28a/b...

... cartilage volume is poorly understood. Here, we provide evidence that Erk signaling during synovial joint development determines articular cartilage thickness in adult mice. Articular cartilage Kras Erk let-7 Lin28 MicroRNA Osteoarthritis National Institutes of Health 10.13039...

...) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells...

...Erica Balzer; Christian Heine; Qiang Jiang; Vivian M. Lee; Eric G. Moss LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block let-7 ( Mirlet7 ) microRNA processing and help promote pluripotency. We have observed LIN28 expression in the developing mouse neural...