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Keywords: Limb regeneration
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Journal Articles
Journal: Development
Development (2022) 149 (5): dev200282.
Published: 11 March 2022
... in the proximal-distal axis of limbs. However, there is no direct genetic evidence that Hox genes are essential for limb development in non-mammalian tetrapods or for limb regeneration. Here, we produced single to quadruple Hox13 paralog mutants using the CRISPR/Cas9 system in newts ( Pleurodeles waltl ), which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199158.
Published: 9 June 2021
...Can Aztekin; Tom W. Hiscock; John Gurdon; Jerome Jullien; John Marioni; Benjamin David Simons ABSTRACT Absence of a specialized wound epidermis is hypothesized to block limb regeneration in higher vertebrates. However, the factors preventing its formation in regeneration-incompetent animals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
... BMP signaling is blocked, but ectopic injection of either human or axolotl protein did not rescue the defects. By administering LDN193189 treatments at different time points during regeneration, we show clearly that limb regeneration progresses in a proximal to distal fashion. This demonstrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev169128.
Published: 2 January 2019
...Stephanie L. Tsai; Clara Baselga-Garriga; Douglas A. Melton ABSTRACT Blastema formation, a hallmark of limb regeneration, requires proliferation and migration of progenitors to the amputation plane. Although blastema formation has been well described, the transcriptional programs that drive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1998) 125 (21): 4175–4184.
Published: 1 November 1998
... limb regeneration Analysis of regenerative capabilities in many teleosts has shown that they have the ability to regenerate their fins after injury. This is restricted to the fin ray structures that enclose the dermal skeleton, since amputation close to the body does not allow fin regeneration...
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (6): 1731–1741.
Published: 1 June 1995
...David M. Gardiner; Bruce Blumberg; Yuriko Komine; Susan V. Bryant ABSTRACT Homeobox genes are important in the regulation of outgrowth and pattern formation during limb development. It is likely that homeobox genes play an equally important role during limb regeneration. We have isolated...
Journal Articles
Journal: Development
Development (1995) 121 (4): 1065–1076.
Published: 1 April 1995
... Msx2 limb regeneration limb development mouse embryo digit tip The ability of limb cells to replace lost parts following injury (regeneration) is known to occur in adult digits of a variety of different mammals including humans ( Douglas, 1972 ; Holm and Zachariae, 1974 ; Illingsworth...
Journal Articles
Journal: Development
Development (1995) 121 (2): 347–357.
Published: 1 February 1995
... for each of the four msx genes during fin development and regeneration and differential regulation of their expression. 08 11 1994 © 1995 by Company of Biologists 1995 blastema Danio rerio developmental patterning limb regeneration The genetic regulation of pattern...
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Journal: Development
Development (1993) 117 (3): 937–945.
Published: 1 March 1993
... and wound epidermis were strongly reactive, although no axial variation in expression was detected. 15 12 1992 © 1993 by Company of Biologists 1993 retinoic acid retinoic acid receptors limb regeneration newts Antibodies RP6 and RP8 gave strong staining of epidermal...
Journal Articles
Journal: Development
Development (1991) 111 (2): 489–496.
Published: 1 February 1991
.... and Brockes , J. P. ( 1988 ). Evidence for dedifferentiation and metaplasia in amphibian limb regeneration from inheritance of DNA methylation . Development 104 , 657 – 668 . 10.1242/dev.104.4.657 Cho , K. W. Y. , Goetz , J. , Wright , C. V. E. , Fritz , A. , Hardwicke...
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Journal: Development
Development (1989) 105 (4): 813–820.
Published: 1 April 1989
...Clifford J. Tabin ABSTRACT Forelimbs and hindlimbs of tetrapods have different morphological patterns. One plausible explanation for the difference is that the cells that give rise to the limbs differentially express genes which control their pattern of development. Amphibian limb regeneration...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 109–119.
Published: 1 April 1989
..., the two sets of data seem to show a similar stage-dependent rise and then decline in the availability of CRABP, implying a role for this molecule in limb regeneration (see below). In an effort to examine the role of CRABP in more detail, we have compared the ability of a range of retinoids...
Journal Articles
Journal: Development
Development (1989) 105 (3): 585–593.
Published: 1 March 1989
... for the axolotl forelimb. We show that the complex forms autonomously in muscleless axolotl limb regenerates produced from a cuff of unirradiated dermis surrounding an irradiated limb stump, and persists for up to a year after amputation. The pattern of other connective tissue structures, including the skeleton...
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