... - 3011 . 10.1242/dev.122.10.2997 Galloway , J. L. , Delgado , I. , Ros , M. A. and Tabin , C. J. ( 2009 ). A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning . Nature 460 , 400 - 404 . 10.1038/nature08117 Gómez-Gaviro , M. V...

... Turing mechanism can reproduce a wide diversity of joint patterns observed in the tetrapod lineage, providing a unifying framework to interrogate joint patterning in the tetrapod limb. Limb patterning Mathematical modelling Turing patterns The acquisition of digits (fingers and toes...

... 2 2008 © 2008. 2008 Apoptosis Autopod progenitors Cell proliferation FGF signaling Limb patterning Mouse Wnt signaling The apical ectodermal ridge (AER) is an essential signaling center governing vertebrate limb development( Capdevila and Izpisua Belmonte,2001 ; Martin...

...( Haycraft et al., 2005 ), the conditional loss of cilia on the ventral ectoderm and AER of the limb bud with msx2cre did not significantly affect limb patterning. This indicates that ciliary function is not required on these cell populations for normal limb development, although a role for cilia...

.... L. and Francis-West, P. ( 2002 ). Wnt signalling during limb development. Int. J. Dev. Biol. 46 , 927 -936. Cygan, J. A., Johnson, R. L. and McMahon, A. P. ( 1997 ). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124 , 5021...

... 2002 © 2002. 2002 Limb patterning Hh Dpp EGF Signalling collier Drosophila melanogaster Proliferation The secreted proteins of the Hedgehog (Hh) family play a crucial role in the patterning of many structures in vertebrates and invertebrates, by providing differentiating...

... mass. These results suggested a role for EphA7 in cell-cell contact-mediated signalling in dorsal limb patterning and/or axon guidance. We carried out experimental manipulations in the chick embryo wing bud to alter the dorsoventral patterning of the limb. The analyses of EphA7 expression...

... hedgehog Polydactyly Doublefoot mutant Mouse Limb patterning The vertebrate limb serves as a model system for studying the control of pattern formation. Classic embryonic studies in the chick limb have revealed three signaling centers, namely the AER (Apical Ectodermal Ridge), ZPA (Zone...

... 1995 Shh peptides CNS patterning limb patterning chick mouse Regulation of axial polarity in the vertebrate central nervous system (CNS), somite and limb appears to depend on intercellular signals. For example, in the CNS, contact-mediated signals emanating from the underlying...

... hedgehog cell-signalling floor-plate induction limb patterning imaginal discs segment polarity genes Although the role of signalling factors in organising cell pop ulations in developing embryos has long been recognised, it is only fairly recently that the molecular nature of these signals...

..., loading both tissues in the graft caused a significant decrease in duplications. This indicates that a major role of gap junctions in limb patterning may be to enable polarising region cells to communicate directly with adjacent anterior mesenchyme. A role for gap junctional communication between anterior...