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Keywords: Limb development
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev180042.
Published: 05 October 2020
... chromatid segregation and promoting daughter cell intercalations that shape the early limb bud. Iroquois Cohesin Limb development Mesodermal cell intercalations Mitotic chromatid segregation Morphogenesis Iroquois (Irx) genes were first identified as regulators of pre-pattern that control...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev190967.
Published: 14 August 2020
... syndrome, and Lowry-Wood syndrome. Similarly, primordial dwarfism in domesticated animals is linked to positive selection in minor spliceosome components. Despite being vital for limb development and size regulation, its role remains unexplored. Here, we disrupt minor spliceosome function in the developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev158550.
Published: 09 April 2018
.../ Summary: Long-range regulatory interactions may have limited predictive value for identifying enhancer mutations with strong loss-of-function phenotypes during development. Enhancer-promoter interactions Genomics Limb development Enhancer loss-of-function mutations Embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev161208.
Published: 29 March 2018
... tendon morphogenesis in the avian hind limb . Development   125 , 4019 - 4032 . Kardon , G. , Harfe , B. D. and Tabin , C. J. ( 2003 ). A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning . Dev. Cell   5 , 937 - 944 . 10.1016/S1534...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev160093.
Published: 08 February 2018
... known as ‘clubfoot’) is a human lower limb developmental defect with a worldwide prevalence of 1-3 cases for every 1000 live births, making it one of the most common pediatric orthopedic conditions ( Cartlidge, 1984 ; Dobbs et al., 2000 ). Clubfoot is characterised by the inward rotation and downward...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev157412.
Published: 08 January 2018
... of Uhrf1 in other processes, such as limb development, is unknown. In this study, we generated limb mesenchymal cell-specific Uhrf1 knockout mice ( Uhrf1 Δ Limb/ Δ Limb , cKO). The cKO mice had short and deformed limbs caused by growth plate irregularities. Given the ability of Uhrf1 to regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2480–2489.
Published: 01 July 2017
... ). The bHLH factor dHAND controls sonic hedgehog expression and establishment of the zone of polarizing activity during limb development . Development   127 , 2461 - 2470 . Chen , Z. F. and Behringer , R. R. ( 1995 ). Twist is required in head mesenchyme for cranial neural tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 479–486.
Published: 01 February 2017
...Patricia Saiz-Lopez; Kavitha Chinnaiya; Matthew Towers; Maria A. Ros ABSTRACT An intrinsic timing mechanism specifies the positional values of the zeugopod (i.e. radius/ulna) and then autopod (i.e. wrist/digits) segments during limb development. Here, we have addressed whether this timing mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
... SOX9 Chondrogenesis Limb development Progenitor cells Differentiating cartilage elements are specified from a highly proliferative mesodermal progenitor population that is specified early in limb development. After specification, progenitor cells coalesce into condensates, activate Sox9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3491–3505.
Published: 01 October 2016
... - 70 . 10.1002/jmor.1050940103 Crawford , K. and Stocum , D. L. ( 1988a ). Retinoic acid proximalizes level-specific properties responsible for intercalary regeneration in axolotl limbs . Development   104 , 703 - 712 . Crawford , K. and Stocum , D. L. ( 1988b...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2994–3001.
Published: 15 August 2016
... the mouse limb . Development   132 , 797 - 803 . 10.1242/dev.01613 Sun , M. , Ma , F. , Zeng , X. , Liu , Q. , Zhao , X.-L. , Wu , F.-X. , Wu , G.-P. , Zhang , Z.-F. , Gu , B. , Zhao , Y.-F. , et al. ( 2008 ). Triphalangeal thumb-polysyndactyly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1672–1683.
Published: 01 May 2015
.... Limb development is a well-studied topic in vertebrate organogenesis. Nevertheless, there is still little understanding of tissue-level deformation relative to molecular and cellular dynamics. This is mainly because live recording of detailed cell behaviors in whole tissues is technically difficult. To...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 672–680.
Published: 15 February 2015
...Idit Eshkar-Oren; Sharon Krief; Napoleone Ferrara; Alison M. Elliott; Elazar Zelzer Blood vessels serve as key regulators of organogenesis by providing oxygen, nutrients and molecular signals. During limb development, programmed cell death (PCD) contributes to separation of the digits...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1906–1914.
Published: 01 May 2014
... 3 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Enhancer Gli Gremlin Limb development Silencer Sonic Hedgehog Mouse The Hedgehog (Hh) pathway is one of the primary signaling mechanisms underlying developmental patterning in organisms ranging from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1715–1725.
Published: 15 April 2014
....292104 Chiang C. , Litingtung Y. , Harris M. P. , Simandl B. K. , Li Y. , Beachy P. A. , Fallon J. F. ( 2001 ). Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function . Dev. Biol. 236 , 421 - 435 . 10.1006/dbio...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4574–4582.
Published: 15 November 2013
.... 20 3 2013 22 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Hox genes Limb development Stromal cells Musculoskeletal integration Connective tissue Mouse The vertebrate limb provides a powerful system for the study of tissue patterning and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2130–2138.
Published: 15 May 2013
...Rushikesh Sheth; Damien Grégoire; Annie Dumouchel; Martina Scotti; Jessica My Trang Pham; Stephen Nemec; Maria Félix Bastida; Marian A. Ros; Marie Kmita Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3180–3188.
Published: 01 September 2012
... Pleasant, MI 48858, USA Competing interests statement The authors declare no competing financial interests. 18 6 2012 © 2012. Tbx5 Hox Limb development T-box genes encode a family of transcription factors that have been identified in all metazoans and which play...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1195–1205.
Published: 15 March 2011
... ) Competing interests statement The authors declare no competing financial interests. 23 12 2010 © 2011. 2011 Limb development Arid3b AER Morphogenesis Organogenesis ARID Mouse Chick Vertebrate limb development is a classic model in embryology for the study of pattern...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1227–1234.
Published: 15 March 2011
...Bernd Boehm; Michael Rautschka; Laura Quintana; Jelena Raspopovic; Žiga Jan; James Sharpe We have created a 2D morphometric analysis of the developing mouse hindlimb bud. This analysis has provided two useful resources for the study of limb development. First, a temporally accurate numerical...
Includes: Supplementary data