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Keywords: Limb
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Journal Articles
Journal: Development
Development (2020) 147 (17): dev177956.
Published: 11 September 2020
...Caitlin McQueen; Matthew Towers ABSTRACT The vertebrate limb continues to serve as an influential model of growth, morphogenesis and pattern formation. With this Review, we aim to give an up-to-date picture of how a population of undifferentiated cells develops into the complex pattern of the limb...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167700.
Published: 22 July 2019
...Alberto Joven; Ahmed Elewa; András Simon ABSTRACT Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev171421.
Published: 15 May 2019
... interests. 29 8 2018 16 4 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ C-met Skeletal muscle Sternohyoideus Lateral line Limb Posterior hypaxial muscle Zebrafish Six1 Six4 In mammals, two homeobox...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156554.
Published: 17 January 2018
.... , Koyama , E. , Enomoto-Iwamoto , M. , Kurisu , K. , Yeh , H. , Abrams , W. R. , Rosenbloom , J. and Pacifici , M. ( 2000 ). Transcription factor ERG variants and functional diversification of chondrocytes during limb long bone development . J. Cell Biol.   150 , 27 - 40...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154054.
Published: 08 January 2018
...Sun-hee Hwang; Kevin A. White; Bandarigoda N. Somatilaka; John M. Shelton; James A. Richardson; Saikat Mukhopadhyay ABSTRACT The role of basal suppression of the sonic hedgehog (Shh) pathway and its interaction with Indian hedgehog (Ihh) signaling during limb/skeletal morphogenesis is not well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 01 June 2017
...Endika Haro; Billy A. Watson; Jennifer M. Feenstra; Luke Tegeler; Charmaine U. Pira; Subburaman Mohan; Kerby C. Oberg Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 601–611.
Published: 15 February 2017
...Matthew Nguyen; Pankhuri Singhal; Judith W. Piet; Sandra J. Shefelbine; Malcolm Maden; S. Randal Voss; James R. Monaghan Salamanders are capable of regenerating amputated limbs by generating a mass of lineage-restricted cells called a blastema. Blastemas only generate structures distal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3839–3851.
Published: 15 October 2016
...Emmanuelle Havis; Marie-Ange Bonnin; Joana Esteves de Lima; Benjamin Charvet; Cécile Milet; Delphine Duprez The molecular programme underlying tendon development has not been fully identified. Interactions with components of the musculoskeletal system are important for limb tendon formation. Limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3481–3490.
Published: 01 October 2016
...Jean-François Denis; Fadi Sader; Samuel Gatien; Éric Villiard; Anie Philip; Stéphane Roy Axolotls are unique among vertebrates in their ability to regenerate tissues, such as limbs, tail and skin. The axolotl limb is the most studied regenerating structure. The process is well characterized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3514–3521.
Published: 01 October 2016
... with Turing-like properties. However, as four of the five digits of the mouse limb are morphologically similar in terms of phalangeal pattern, it has been suggested that self-organization alone could be sufficient. Here, we show that inhibition of Shh signalling at a specific stage of chick wing development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2548–2560.
Published: 15 July 2016
... regulator in limb patterning. Harnessing an osteogenic lineage-specific Shox2 inactivation approach we show that despite widespread Shox2 expression in multiple cell lineages, lack of the stylopod observed upon Shox2 deficiency is a specific result of Shox2 loss of function in the osteogenic lineage. ChIP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4340–4350.
Published: 15 December 2015
... to express a high number of genes that are associated with chondrogenesis, including several extracellular matrix proteins and transcription factors that regulate chondrogenesis. Therefore, we compared regions of putative SOX9 DNA binding between E12.5 heart valves and E12.5 limb buds. We identified context...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2431–2441.
Published: 15 July 2015
...Alice H. Huang; Timothy J. Riordan; Brian Pryce; Jennifer L. Weibel; Spencer S. Watson; Fanxin Long; Veronique Lefebvre; Brian D. Harfe; H. Scott Stadler; Haruhiko Akiyama; Sara F. Tufa; Douglas R. Keene; Ronen Schweitzer The long tendons of the limb extend from muscles that reside in the zeugopod...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4194–4198.
Published: 01 November 2014
...Julia E. VanderMeer; Robin P. Smith; Stacy L. Jones; Nadav Ahituv The limb is widely used as a model developmental system and changes to gene expression patterns in its signaling centers, notably the zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER), are known to cause limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 01 October 2014
... identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis ( Scx ) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3605–3611.
Published: 15 September 2014
..., the addition of nuclei in limb muscles is three times more rapid than in trunk and is tightly associated with fiber growth. A complex interaction takes place in the trunk, where primary myotome cells from the medial somite border rarely fuse to one another, but readily do so with anterior and posterior border...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2885–2894.
Published: 15 July 2014
...Natsuno Suda; Takehiko Itoh; Ryuichiro Nakato; Daisuke Shirakawa; Masashige Bando; Yuki Katou; Kohsuke Kataoka; Katsuhiko Shirahige; Cheryll Tickle; Mikiko Tanaka Apoptosis is an important mechanism for sculpting morphology. However, the molecular cascades that control apoptosis in developing limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 513–518.
Published: 01 February 2013
...Eugen Nacu; Mareen Glausch; Huy Quang Le; Febriyani Fiain Rochel Damanik; Maritta Schuez; Dunja Knapp; Shahryar Khattak; Tobias Richter; Elly M. Tanaka During salamander limb regeneration, only the structures distal to the amputation plane are regenerated, a property known as the rule of distal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 583–593.
Published: 01 February 2013
... initiation and changes in distribution and number of mammary precursor cells leading to abnormal morphology, number and position of mammary placodes. These Lrp4 mammary defects, as well as limb defects, were associated with elevated Wnt/β-catenin signaling and were rescued by reducing the dose of the Wnt co...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 1910–1920.
Published: 01 June 2012
...-cell-autonomous regulatory pathways must tightly control MyoD expression to ensure correct initiation of the muscle program at different places in the embryo and at different developmental times. In the present study, we have addressed the involvement of Sim2 (single-minded 2) in limb embryonic...
Includes: Supplementary data