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Keywords: Lgr5
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Journal Articles
In collection:
Musculoskeletal system
Lauren Bobzin, Audrey Nickle, Sebastian Ko, Michaela Ince, Aaron Huang, Arshia Bhojwani, Ryan Roberts, Amy E. Merrill
Journal:
Development
Development (2025) 152 (2): dev204264.
Published: 20 January 2025
... spot in the infant skull. Frontal suture FGF Fgfr2 Scx Anterior fontanelle WNT Calvaria Lgr5 Craniofacial Mouse National Institute of Dental and Craniofacial Research http://dx.doi.org/10.13039/100000072 R01 DE025222 T90 DE021982 F31 DE032259 R35 DE034346...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Nicole Prior, Christopher J. Hindley, Fabian Rost, Elena Meléndez, Winnie W. Y. Lau, Berthold Göttgens, Steffen Rulands, Benjamin D. Simons, Meritxell Huch
Journal:
Development
Development (2019) 146 (12): dev174557.
Published: 12 June 2019
... the adult stem cell marker Lgr5 , and generate both hepatocyte and cholangiocyte progeny that persist for the lifespan of the mouse. Combining lineage tracing and scRNA-seq, we show that Lgr5 marks E9.5-E10.0 bipotent liver progenitors residing at the apex of a hepatoblast hierarchy. Furthermore, isolated...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Maria Sanz-Navarro, Kerstin Seidel, Zhao Sun, Ludivine Bertonnier-Brouty, Brad A. Amendt, Ophir D. Klein, Frederic Michon
Journal:
Development
Development (2018) 145 (1): dev155929.
Published: 8 January 2018
... to growth defects and impairment of ameloblast lineage commitment. Deletion of Sox2 specifically in Sox2 + cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2 -expressing cell population. Furthermore, we show that Lgr5 -expressing cells...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2017) 144 (17): 3080–3094.
Published: 1 September 2017
... , M. , Tan , S. , Van Es , J. H. , Huch , M. , et al. ( 2012 ). Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development . Cell Rep. 2 , 540 - 552 . 10.1016/j.celrep.2012.08.018 Basta , J. and Rauchman , M. ( 2015...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Bhopal Mohapatra, Neha Zutshi, Wei An, Benjamin Goetz, Priyanka Arya, Timothy A. Bielecki, Insha Mushtaq, Matthew D. Storck, Jane L. Meza, Vimla Band, Hamid Band
Journal:
Development
Development (2017) 144 (6): 1072–1086.
Published: 15 March 2017
... system. However, their physiological roles in epithelial tissues are unknown. Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a tamoxifen-inducible mammary stem cell (MaSC)-specific Cbl and Cbl-b double knockout ( Cbl/Cbl-b DKO) using Lgr5-EGFP-IRES-CreERT2...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Valeria Fernandez Vallone, Morgane Leprovots, Sandra Strollo, Gabriela Vasile, Anne Lefort, Frederick Libert, Gilbert Vassart, Marie-Isabelle Garcia
Journal:
Development
Development (2016) 143 (9): 1452–1463.
Published: 1 May 2016
... from adult glandular Lgr5 + stem cells, but appeared highly related to fetal intestinal spheroids. Although they shared a common spheroid signature, intestinal and gastric fetal spheroid-generating cells expressed organ-specific transcription factors and were committed to intestinal and glandular...
Includes: Supplementary data
Journal Articles
Brandon C. Cox, Renjie Chai, Anne Lenoir, Zhiyong Liu, LingLi Zhang, Duc-Huy Nguyen, Kavita Chalasani, Katherine A. Steigelman, Jie Fang, Alan G. Cheng, Jian Zuo
Journal:
Development
Development (2014) 141 (4): 816–829.
Published: 15 February 2014
.../+ ; Lgr5 CreER/+ ; ROSA26 CAG-tdTomato/+ mice with tamoxifen and DT at P1, followed by the mitotic tracer EdU at P3-P5. At P7, we observed 6.7±0.6 EdU + /Myo7a + /tdTomato + cells in the whole apical turn and none in the middle and basal turns ( Fig. 6A-G ; supplementary material Table S2E ; n =3...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2013) 140 (12): 2484–2494.
Published: 15 June 2013
.... Published by The Company of Biologists Ltd 2013 Lgr5 R-Spondin Stem Wnt The leucine-rich repeat (LRR)-containing G-protein-coupled receptor 4/5/6 (Lgr4/5/6) gene family was originally identified via in silico screens for cDNAs that encode proteins with homology to the glycoprotein hormone...
Journal Articles
Journal:
Development
Development (2012) 139 (20): 3741–3751.
Published: 15 October 2012
... outer layer, which is contiguous and shares markers (e.g. Lgr5) with the basal ORS but is formed by a separate lineage that belongs neither to the ORS nor Cp lineage. It represents a novel element with proximal cells that are contiguous with the germinative layer in the bulb. In reference to its shape...
Includes: Multimedia, Supplementary data
Journal Articles
Kelli L. VanDussen, Alexis J. Carulli, Theresa M. Keeley, Sanjeevkumar R. Patel, Brent J. Puthoff, Scott T. Magness, Ivy T. Tran, Ivan Maillard, Christian Siebel, Åsa Kolterud, Ann S. Grosse, Deborah L. Gumucio, Stephen A. Ernst, Yu-Hwai Tsai, Peter J. Dempsey, Linda C. Samuelson
Journal:
Development
Development (2012) 139 (3): 488–497.
Published: 1 February 2012
.... To confirm that Notch pathway inhibition regulates CBC stem cells, we measured the expression of the marker genes Olfm4, Lgr5 and Ascl2 . This revealed a striking reduction in Olfm4 mRNA abundance in DBZ-treated intestine ( Fig. 2A ), to an extent greater than the decrease in GFP-stained CBC cell number...
Includes: Supplementary data