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Keywords: Lgr5
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Journal Articles
Journal: Development
Development (2025) 152 (2): dev204264.
Published: 20 January 2025
... spot in the infant skull. Frontal suture FGF Fgfr2 Scx Anterior fontanelle WNT Calvaria Lgr5 Craniofacial Mouse National Institute of Dental and Craniofacial Research http://dx.doi.org/10.13039/100000072 R01 DE025222 T90 DE021982 F31 DE032259 R35 DE034346...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev174557.
Published: 12 June 2019
... the adult stem cell marker Lgr5 , and generate both hepatocyte and cholangiocyte progeny that persist for the lifespan of the mouse. Combining lineage tracing and scRNA-seq, we show that Lgr5 marks E9.5-E10.0 bipotent liver progenitors residing at the apex of a hepatoblast hierarchy. Furthermore, isolated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155929.
Published: 8 January 2018
... to growth defects and impairment of ameloblast lineage commitment. Deletion of Sox2 specifically in Sox2 + cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2 -expressing cell population. Furthermore, we show that Lgr5 -expressing cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3080–3094.
Published: 1 September 2017
... , M. , Tan , S. , Van Es , J. H. , Huch , M. , et al. ( 2012 ). Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development . Cell Rep.   2 , 540 - 552 . 10.1016/j.celrep.2012.08.018 Basta , J. and Rauchman , M. ( 2015...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1072–1086.
Published: 15 March 2017
... system. However, their physiological roles in epithelial tissues are unknown. Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a tamoxifen-inducible mammary stem cell (MaSC)-specific Cbl and Cbl-b double knockout ( Cbl/Cbl-b DKO) using Lgr5-EGFP-IRES-CreERT2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1452–1463.
Published: 1 May 2016
... from adult glandular Lgr5 + stem cells, but appeared highly related to fetal intestinal spheroids. Although they shared a common spheroid signature, intestinal and gastric fetal spheroid-generating cells expressed organ-specific transcription factors and were committed to intestinal and glandular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 816–829.
Published: 15 February 2014
.../+ ; Lgr5 CreER/+ ; ROSA26 CAG-tdTomato/+ mice with tamoxifen and DT at P1, followed by the mitotic tracer EdU at P3-P5. At P7, we observed 6.7±0.6 EdU + /Myo7a + /tdTomato + cells in the whole apical turn and none in the middle and basal turns ( Fig. 6A-G ; supplementary material Table S2E ; n =3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2484–2494.
Published: 15 June 2013
.... Published by The Company of Biologists Ltd 2013 Lgr5 R-Spondin Stem Wnt The leucine-rich repeat (LRR)-containing G-protein-coupled receptor 4/5/6 (Lgr4/5/6) gene family was originally identified via in silico screens for cDNAs that encode proteins with homology to the glycoprotein hormone...
Journal Articles
Journal: Development
Development (2012) 139 (20): 3741–3751.
Published: 15 October 2012
... outer layer, which is contiguous and shares markers (e.g. Lgr5) with the basal ORS but is formed by a separate lineage that belongs neither to the ORS nor Cp lineage. It represents a novel element with proximal cells that are contiguous with the germinative layer in the bulb. In reference to its shape...
Includes: Multimedia, Supplementary data
Journal Articles