... interactions between xenopus lefty and BMP4 signaling . Dev. Biol.   223 , 291 - 306 . 10.1006/dbio.2000.9739 Brennan , J. , Norris , D. P. and Robertson , E. J. ( 2002 ). Nodal activity in the node governs left-right asymmetry . Genes Dev.   16 , 2339 - 2344 . 10.1101/gad.1016202...

... development by antagonism of lefty and nodal signaling . Development 126 , 3253 - 3262 . Bisgrove B. W. , Morelli S. H. , Yost H. J. ( 2003 ). Genetics of human laterality disorders: insights from vertebrate model systems . Annu. Rev. Genomics Hum. Genet. 4 , 1 - 32...

... with neuroectoderm patterning mechanisms along the DV axes of other bilaterian embryos. It operates along an axis orthogonal to the canonical Wnt system, which specifies cell fates along the AP axis. Although nodal, lefty, bmp2/4 and chordin are all transcribed on the ventral side of the sea urchin embryo, BMP2...

... (here, Xnr1 or Nodal1 in Xenopus ) and Lefty interact in a cross-regulatory relationship in mesendoderm induction, and are the conserved instructors of left-right (LR) asymmetry in early somitogenesis stage embryos. By expressing Xnr1 and Lefty proproteins that produce mature functional epitope-tagged...

... downregulate goosecoid on the dorsal side, but in contrast to earlier reports that nodal and lefty are upstream of pitx2 , ectopic pitx2c in other regions induces cyclops, lefty2 and goosecoid expression. Asymmetric isoform expression occurs in non-overlapping domains, with pitx2c in left dorsal diencephalon...

...Abby M. S. Cheng; Bernard Thisse; Christine Thisse; Christopher V. E. Wright ABSTRACT In mouse, lefty genes play critical roles in the left-right (L-R) axis determination pathway. Here, we characterize the Xenopus lefty-related factor antivin (Xatv). Xatv expression is first observed...

... demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm patterning and goosecoid, no tail and pitx2 expression. In late somite-stage embryos, lft1 and lft2 are expressed asymmetrically in the left diencephalon and left lateral plate respectively, suggesting an additional...

...Claire Chazaud; Pierre Chambon; Pascal Dollé ABSTRACT Determination of the left-right position (situs) of visceral organs involves lefty, nodal and Pitx2 genes that are specifically expressed on the left side of the embryo. We demonstrate that the expression of these genes is prevented...