... that attenuates Hedgehog signaling, regulating left-right asymmetry of organs as well as patterning and morphogenesis of multiple tissues in the embryo. Hedgehog signaling Smoothened Gene-environment interactions Left-right patterning Morphogen Structural birth defects National Institutes...

... suggested some parallels, but also differences, between left-right patterning in mouse and zebrafish. To address these discrepancies, we generated single and double zebrafish mutants for southpaw ( spaw , the Nodal ortholog), dand5 and lefty1 , and performed biochemical and activity assays with Spaw and Vg1...

... pathway, Sdc2 and Tbx16 also control KV ciliogenesis. Our results uncover a novel Sdc2-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis. 19 7 2013 © 2013. Published by The Company of Biologists Ltd 2013 Fgf2 Kupffer’s vesicle Left-right patterning Syndecan 2...

...-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac . J. Biol. Chem. 284 , 33561 – 33570 . Lee J. D. , Migeotte I. , Anderson K. V. ( 2010 ). Left-right patterning in the mouse requires...

... that an RBP named Cugbp, Elav-like family member 1 (Celf1) controls expression of a gene named doublesex and mab-3 related transcription factor 2a ( dmrt2a ), which is essential for somite symmetry and left-right patterning during zebrafish development. Celf1 promotes dmrt2a mRNA decay by binding to UGU...

... development . Biophys. J. 89 , 2199 - 2209 . Chen J. N. , van Eeden F. J. , Warren K. S. , Chin A. , Nusslein-Volhard C. , Haffter P. , Fishman M. C. ( 1997 ). Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish . Development 124...

... equally to this work 14 3 2007 © 2007. 2007 Left-right patterning Calcium homeostasis Cilia Zebrafish The placement and anatomy of the internal organs are asymmetric with respect to the left-right (LR) axis in vertebrates, even though the external body plan appears...

.../GDF1 signals in the early establishment of the mesendoderm and later visceral left-right patterning. Antisense knockdown of the only known frog EGF-CFC factor (FRL1), however, has argued against an essential role for this factor in nodal/GDF1 signaling. To address this apparent paradox, we have...

...: University of Wisconsin, Madison, WI 53706, USA 23 12 2004 ©2005. 2005 Left-right patterning Cilia Kupffer's vesicle Dorsal forerunner cells Left-right dynein Organogenesis The external body plan of vertebrates is bilaterally symmetric, but many internal organs, including...

[email protected] ) 15 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 One of the primary patterning decisions required...

... be properly rescued in Raldh2 − /− embryos, leading to outflow tract septation defects. Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 Retinoic acid (RA), the active metabolite of vitamin...