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Keywords: Lef1
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Journal Articles
Journal: Development
Development (2016) 143 (6): 1041–1054.
Published: 15 March 2016
... of publication. Dr Steven Artandi provided Actin:rtTA mice. Dr Jill Helms shared Lef1 -null tissue sections to validate the specificity of the anti-Lef1 antibody. We thank Andrew McKay, Brynn Akerberg, Astra Henner, Sarah Casper, Yujung Choi and Gene Ma for technical help and Stankunas lab members...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2387–2397.
Published: 1 June 2013
... studies showed that neuromasts are deposited closer together and the PLLp terminates prematurely in lef1 -deficient zebrafish embryos. It was suggested that this results from reduced proliferation in the leading domain of the PLLp and/or premature incorporation of progenitors into proto-neuromasts. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3921–3930.
Published: 15 September 2011
... in the leading zone of the primordium and global Wnt inactivation leads to dramatic disorganization of the primordium and a loss of proto-NM formation. However, the exact cellular events that are regulated by the Wnt pathway are not known. We identified a mutant strain, lef1 nl2 , that contains a lesion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4451–4461.
Published: 15 November 2006
... through Lef1 to regulate neurogenesis in the zebrafish hypothalamus. We show that Lef1 is required for proneural and neuronal gene expression, and for neuronal differentiation in the posterior hypothalamus. Furthermore, we find that this process is dependent on Wnt8b, a ligand of the canonical pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (21): 5241–5255.
Published: 1 November 2003
... LRC and induces differentiation of sebocytes within the interfollicular epidermis. Expression of N-terminally truncated Lef1 to block β-catenin signalling induces transdifferentiation of hair follicles into interfollicular epidermis and sebocytes and causes loss of LRC primarily through proliferation...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2541–2553.
Published: 15 May 2002
... and Edar in wild type as well as Tabby and Lef1 mutant mouse embryos. We show that Eda and Edar expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar signaling in the interactions between the ectodermal compartments and the formation and function of hair...
Journal Articles
Journal: Development
Development (2002) 129 (1): 53–60.
Published: 1 January 2002
... of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b , both of which fail to develop normal mammary glands. Mammary placode induction involves two different...
Journal Articles
Journal: Development
Development (2002) 129 (1): 95–109.
Published: 1 January 2002
...Catherin Niemann; David M. Owens; Jörg Hülsken; Walter Birchmeier; Fiona M. Watt To examine the consequences of repressing β-catenin/Lef1 signalling in mouse epidermis, we expressed a ΔNLef1 transgene, which lacks the β-catenin binding site, under the control of the keratin 14 promoter. No skin...
Journal Articles
Journal: Development
Development (2001) 128 (15): 2915–2927.
Published: 1 August 2001
... cooperate with each other to regulate axis formation in the normal embryo. §Author for correspondence (e-mail: c.stern@ucl.ac.uk ) 30 4 2001 © 2001. 2001 Marginal zone Induction Primitive streak Gastrulation Nieuwkoop centre Vg1 Wnt Lef1 β-catenin JNK Crescent Dickkopf...