... inactivation of Sox2 demonstrates the requirement of Sox2 for maintenance of the DESCs in adult mice. Conditional overexpression of Lef-1 in mice increases DESC proliferation and creates a new labial cervical loop stem cell compartment, which produces rapidly growing long tusk-like incisors, and Lef-1...

... Lef-1/TCF) to multiple binding sites within a Wg-responsive enhancer that is located in 5′ flanking regions of the slp1 gene. Based upon our genetic and molecular analysis, we conclude that Wg signaling induces striped expression of Slp in the mesoderm. Mesodermal Slp is then sufficient to abrogate...

...Mariëtte Oosterwegel; Marc van de Wetering; Janneke Timmerman; Ada Kruisbeek; Olivier Destree; Frits Meijlink; Hans Clevers ABSTRACT The recent identification of a number of T lymphocytespecific enhancers has allowed the cloning of several novel transcription factors. Two of these, TCF-1 and LEF-1...