...Veena Kinare; Archana Iyer; Hari Padmanabhan; Geeta Godbole; Tooba Khan; Zeba Khatri; Upasana Maheshwari; Bhavana Muralidharan; Shubha Tole ABSTRACT The protein co-factor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-HD) proteins in a tetrameric complex consisting...

... to form functional complexes that regulate cell proliferation and differentiation. Using conditional mutagenesis and comparative phenotypic analysis, we analyze the function of Ldb1 and Ldb2 in mouse retinal development, and demonstrate overlapping and specific functions of both proteins. Ldb1 interacts...

... Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription. NLI Ldb1 Isl1 Lhx3 Motor neuron V2a-interneuron Spinal cord The LIM homeodomain (LIM-HD) family...

.... Simultaneous loss of Lhx2 and Lhx9 function resulted in patterning and growth defects along the AP and the PD limb axes. Similar, but more severe, phenotypes were observed when the activities of all three factors, Lmx1b, Lhx2 and Lhx9, were significantly reduced by removing their obligatory co-factor Ldb1...

...Natalia Meier; Sanja Krpic; Patrick Rodriguez; John Strouboulis; Maria Monti; Jeroen Krijgsveld; Martin Gering; Roger Patient; Arnd Hostert; Frank Grosveld Ldb1, a ubiquitously expressed LIM domain binding protein, is essential in a number of tissues during development. It interacts with Gata1...

...) proteins is regulated by their interactions with various factors that bind to the LIM domain. We show that reduced expression of single-stranded DNA-binding protein 1 ( Ssdp1 ), which encodes a co-factor of LIM domain interacting protein 1 (Ldb1), in the mouse mutant headshrinker ( hsk )disrupts anterior...

...Ichiro Hiratani; Naoko Yamamoto; Toshiaki Mochizuki; Shin-ya Ohmori; Masanori Taira The Xenopus LIM homeodomain (LIM-HD) protein, Xlim-1, is expressed in the Spemann organizer and cooperates with its positive regulator, Ldb1, to activate organizer gene expression. While this activation...

...Mahua Mukhopadhyay; Andreas Teufel; Tsuyoshi Yamashita; Alan D. Agulnick; Lan Chen; Karen M. Downs; Alice Schindler; Alexander Grinberg; Sing-Ping Huang; David Dorward; Heiner Westphal The LIM domain-binding protein 1 (Ldb1) is found in multi-protein complexes containing various combinations of LIM...