..., in the development and function of the zebrafish node. We show jnk1 and jnk2 specify length of nodal cilia, generate flow in the node and restrict southpaw to the left lateral plate mesoderm. Moreover, loss of asymmetric southpaw expression does not result in disturbances to asymmetric organ placement, supporting...

...Julia Grzymkowski; Brent Wyatt; Nanette Nascone-Yoder ABSTRACT Many organs develop left-right asymmetric shapes and positions that are crucial for normal function. Indeed, anomalous laterality is associated with multiple severe birth defects. Although the events that initially orient the left-right...

... ( [email protected] ) 21 9 2009 © 2009. 2009 Arl13b Scorpion Cilium Joubert syndrome Kidney cyst Laterality Joubert syndrome (JS) is an autosomal recessive disorder characterized by a malformation of the cerebellum, hypotonia, oculomotor apraxia, ataxia, abnormal breathing...

...Igor Schneider; Douglas W. Houston; Michael R. Rebagliati; Diane C. Slusarski Establishment of the left-right axis is essential for normal organ morphogenesis and function. Ca 2+ signaling and cilia function in the zebrafish Kuppfer's Vesicle (KV) have been implicated in laterality. Here we...

... of which display defects in organ positioning that resemble human heterotaxia, as well as abnormalities in asymmetric gene expression in the lateral plate mesoderm (LPM) and dorsal diencephalon of the brain. Interestingly, mouse and zebrafish pkd2 -/- mutants have disparate effects on nodal expression...

...Ann F. Ramsdell; Jayne M. Bernanke; Thomas C. Trusk The significant morbidity and mortality associated with laterality disease almost always are attributed to complex congenital heart defects (CHDs),reflecting the extreme susceptibility of the developing heart to disturbances in the left-right (LR...

...-fate decision is controlled by a complex gene regulatory network composed of microRNAs (miRNAs) and transcription factors. Alterations in the activities of each of these regulatory factors cause a complete lateral cell-fate switch. Here, we describe lsy-2 , a novel C2H2 zinc finger transcription factor...

... by which the heart interprets lateralizing signals from the midline. ‡ Author for correspondence (e-mail: [email protected] ) * These authors contributed equally † Current address:Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK 12 08 1997 © 1997...

.... Of the four Xenopus nodal-related genes expressed during gastrulation, only Xnr-1 is re-expressed unilaterally in the left lateral plate mesoderm at neurula/tailbud stages. Here, we show that the asymmetric expression of Xnr-1 can be made bilaterally symmetric by right-sided microinjection of RNA encoding...

... of Biologists 1990 asymmetry handedness laterality isomerism heterotaxia The development of handed asymmetry is a deep and neglected problem. Deep because it involves a type of spatial ordering of a quite special nature for which there are just no models, and neglected for, probably, just...

...Nigel A. Brown; Christine I. Hoyle; Afshan McCarthy; Lewis Wolpert ABSTRACT We are studying the development of handedness, in particular the relationships between handed structures with bilateral symmetry, for example the limbs, and those with lateral asymmetry, such as the heart, lungs and gut...