...Uma M. Neelathi; Damian Dalle Nogare; Ajay B. Chitnis ABSTRACT The zebrafish posterior lateral line primordium migrates along a path defined by the chemokine Cxcl12a, periodically depositing neuromasts, to pioneer formation of the zebrafish posterior lateral line system. snail1b , known for its...

... development, using dental placodes, hair follicles, taste buds, lung neuroendocrine cells and lateral line neuromasts as examples. Hair follicle placode Lateral line primordium Lung neuroendocrine cell body Molar tooth placode Slithering Taste bud In vertebrates, an array of small...

... posterior lateral line primordium (pLLp), a group of ∼100 cells that migrates along the trunk during embryonic development to form the lateral line mechanosensory system. During migration, the pLLp deposits rosettes from the trailing edge, while cells are polarized and incorporated into nascent rosettes...

.... These findings reveal a novel chemotactic role for Fgf signalling in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern into a compact group of migrating cells. Fig. 1. SPCs have placode identity and fuse with the main primordium. All images are lateral views...

... interactions coordinate collective cell migration of the posterior lateral line primordium . Cell Adh. Migr. 3 , 365 - 368 . Aman A. , Nguyen M. , Piotrowski T. ( 2010 ). Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis . Dev. Biol. 349...

.... Cells of the zebrafish lateral line primordium switch from mesenchyme-like leader cells to epithelial rosettes that develop into mechanosensory organs. Here, we show that this transition is regulated by an Fgf signaling circuit that is active within the migrating primordium. Point sources of Fgf ligand...