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Keywords: Lar
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Journal Articles

Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche

Harleen Kaur, Shiv Kumar Sharma, Sudip Mandal, Lolitika Mandal
Journal: Development
Development (2019) 146 (24): dev178202.
https://doi.org/10.1242/dev.178202
Published: 23 December 2019
... uncovered a novel function of Lar , a receptor protein tyrosine phosphatase. Niche-specific loss of Lar leads to upregulated insulin signaling, causing increased niche cell proliferation and ectopic progenitor differentiation. Insulin signaling assayed by PI3K activation is downregulated after the second...
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Includes: Supplementary data
Journal Articles

The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis

Robert J. Harrington, Michael J. Gutch, Michael O. Hengartner, Nicholas K. Tonks, Andrew D. Chisholm
Journal: Development
Development (2002) 129 (9): 2141–2153.
https://doi.org/10.1242/dev.129.9.2141
Published: 1 May 2002
...Robert J. Harrington; Michael J. Gutch; Michael O. Hengartner; Nicholas K. Tonks; Andrew D. Chisholm Receptor-like protein-tyrosine phosphatases (RPTPs) form a diverse family of cell surface molecules whose functions remain poorly understood. The LAR subfamily of RPTPs has been implicated in axon...
View article titled, The C. elegans <span class="search-highlight">LAR</span>-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis
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Journal Articles

The receptor-like tyrosine phosphatase Lar is required for epithelial planar polarity and for axis determination with Drosophila ovarian follicles

Horacio M. Frydman, Allan C. Spradling
Journal: Development
Development (2001) 128 (16): 3209–3220.
https://doi.org/10.1242/dev.128.16.3209
Published: 15 August 2001
... tyrosine phosphatase Lar that disorganize follicle formation, block egg chamber elongation and disrupt Oskar localization, which is an indicator of oocyte anterior-posterior polarity. Alterations in actin filament organization correlate with these defects. Actin filaments in the basal follicle cell domain...
View article titled, The receptor-like tyrosine phosphatase <span class="search-highlight">Lar</span> is required for epithelial planar polarity and for axis determination with Drosophila ovarian follicles
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