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Keywords: Laminin
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Journal Articles
Journal: Development
Development (2023) 150 (16): dev201640.
Published: 17 August 2023
... be demonstrated by depleting laminin, which causes normally quiescent embryonic PGCs to proliferate. We show that following laminin depletion, niche cells relay proliferation-inducing signals from the gonadal BM to PGCs via integrin receptors. Disrupting the BM proteoglycan perlecan blocks PGC proliferation when...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (17): dev200610.
Published: 13 September 2022
...Saptarshi Biswas; Sanjid Shahriar; Nicholas P. Giangreco; Panos Arvanitis; Markus Winkler; Nicholas P. Tatonetti; William J. Brunken; Tyler Cutforth; Dritan Agalliu ABSTRACT Neurovascular unit and barrier maturation rely on vascular basement membrane (vBM) composition. Laminins, a major vBM...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (17): dev200640.
Published: 5 September 2022
... to radially sort and myelinate peripheral axons. Elevation of cAMP, but not Rac1 activity, in csp −/− restores myelin ensheathment. Most importantly, we show a significant decrease in laminin expression within csp −/− posterior lateral line nerve and that forcing Laminin 2 expression in csp −/− fully restores...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200456.
Published: 16 May 2022
... composition and mechanical properties of the basement membrane underlying the follicle epithelium of Drosophila egg chambers. We find that the Laminin and Collagen IV networks largely persist in the absence of the other components. Moreover, we show that Perlecan and Collagen IV, but not Laminin or Nidogen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
... simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is driven by deployment of cells from the second heart field (SHF) into both poles of the heart. Laminin is a core component of the extracellular matrix and, although mutations in laminin subunits are linked with cardiac...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (16): dev172668.
Published: 29 August 2019
...Maqsood Ahmed; Leandro N. Marziali; Ernest Arenas; M. Laura Feltri; Charles ffrench-Constant ABSTRACT Development of the central nervous system requires coordination of the proliferation and differentiation of neural stem cells. Here, we show that laminin alpha 2 (lm-α2) is a component...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (8): 1375–1387.
Published: 15 April 2016
... interests The authors declare no competing or financial interests. 25 9 2015 18 2 2016 Here we show that depletion of Laminin from muscle sheath BM causes a progressive, dystrophic phenotype in this tissue. We then use the resulting changes in muscle sheath contractility to probe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (2): 320–330.
Published: 15 January 2015
... morphology along the proximo-distal axis. This epithelial pattern is strictly correlated with the gradient of canonical Wnt signalling activity. By combining genetic analyses with cellular imaging, we show that canonical Wnt signalling regulates epithelial cell morphology by modulating the levels of laminins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2734–2745.
Published: 1 July 2013
.... We identified a mutation affecting zebrafish laminin β1a ( lamb1a ) that disrupts left-right asymmetry of the liver and pancreas. In these mutants, the liver spans the midline and the ventral pancreatic bud remains split into bilateral structures. We show that lamb1a regulates asymmetric left-right...
Journal Articles
Journal: Development
Development (2013) 140 (9): 2050–2060.
Published: 1 May 2013
... a laminin-containing basement membrane - the inner limiting membrane. Genetic deletion of the laminin β2 and γ3 chains affects astrocyte migration and spatial distribution. We show that laminins act as haptotactic factors in vitro in an isoform-specific manner, inducing astrocyte migration and promoting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2050–2060.
Published: 1 June 2012
... polarize with apical localization of the PAR-3 protein complex, then undergo apical constriction to form a cylindrical cyst. We show that laminin, but not other basement membrane components, orients the polarity of the double plate cells. Our results provide in vivo evidence that laminin has an early role...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4165–4176.
Published: 15 December 2009
...Jose M. Urbano; Catherine N. Torgler; Cristina Molnar; Ulrich Tepass; Ana López-Varea; Nicholas H. Brown; Jose F. de Celis; Maria D. Martín-Bermudo Laminins are heterotrimeric molecules found in all basement membranes. In mammals, they have been involved in diverse developmental processes, from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3495–3504.
Published: 15 October 2009
...Claire Anderson; Sólveig Thorsteinsdóttir; Anne-Gaëlle Borycki Basement membranes have essential structural and signalling roles in tissue morphogenesis during embryonic development, but the mechanisms that control their formation are still poorly understood. Laminins are key components...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1071–1081.
Published: 1 April 2009
... function locally promotes basement membrane dissolution in the primary mouth primordium. Consistently, Frzb-1 overexpression decreases RNA levels of the essential basement membrane genes fibronectin and laminin ,whereas Wnt-8 overexpression increases the levels of these RNAs. These data are the first...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 415–426.
Published: 1 February 2009
...,Ontario, Canada). * Author for correspondence (e-mail: timothy.kennedy@mcgill.ca ) 21 11 2008 © 2009. 2009 Oligodendroglia Myelination Myelin Netrin Integrin Laminin Autocrine Mouse Rat FAK (Ptk2) N-WASP (Wasl) To form a myelin sheath, an oligodendrocyte...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (16): 3245–3254.
Published: 15 August 2006
... examined a potential role of direct signalling from the BM to radial glial cells in three mouse mutants where radial glia attachment to the BM is disrupted. This is the case if the nidogen-binding site of the laminin γ1 chain is mutated, in the absence of α6 integrin or of perlecan, an essential BM...
Includes: Supplementary data